Category: pyridine-derivatives

In 2022,Pisacic, Mateja; Kodrin, Ivan; Trninic, Amanda; Djakovic, Marijana published an article in Chemistry of Materials. The title of the article was 《Two-Dimensional Anisotropic Flexibility of Mechanically Responsive Crystalline Cadmium(II) Coordination Polymers》.Formula: C6H4N2 The author mentioned the following in the article:

Crystals of a family of six one-dimensional (1D) coordination polymers of cadmium(II) with cyanopyridines ([CdX2L2]n; X = Cl, Br, I; L = 3-cyanopyridine, 3-CNpy, 4-cyanopyridine, 4-CNpy) presented a variety of morphologies and mech. responses with dominant 2D-anisotropic flexibility, which has not been previously reported. All mech. adaptable crystals were 2D flexible and they displayed a variety of direction-dependent responses; in addition to 2D-isotropic flexibility observed for solely elastic materials, 2D-anisotropic flexibility was noticed for both elastic and elastic → plastic crystals. The consequences of fine and controlled structural variations on mech. behavior were addnl. explored via microfocus SCXRD and complementary theor. studies, revealing that the relative strength and direction of the hydrogen bonding interactions were the key parameters in delivering a specific mech. response. In the experiment, the researchers used many compounds, for example, 4-Cyanopyridine(cas: 100-48-1Formula: C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Formula: C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Arroyo Negrete, Missael Antonio; Wrobel, Kazimierz; Yanez Barrientos, Eunice; Corrales Escobosa, Alma Rosa; Enciso Donis, Israel; Wrobel, Katarzyna published an article in Talanta. The title of the article was 《Determination of chromium(III) picolinate in dietary supplements by flow injection – electrospray ionization – tandem mass spectrometry, using cobalt(II) picolinate as internal standard》.Application In Synthesis of Picolinic acid The author mentioned the following in the article:

In this work, a principle of flow injection anal. (FIA) was applied for sample introduction to an electrospray ionization – ion trap mass spectrometer (ESI-ITMS) with the aim to quantify chromium(III) picolinate (CrPic3) in com. supplements by multiple reaction monitoring, and using cobalt(II) picolinate as internal standard (IS). FIA system was operated with ammonium formate 10 mmol L-1 in methanol-water (1:1, volume/volume) as a carrier solution at a flow rate 200μL min-1; 100μL injections were performed in 2-min intervals. Setting ion transitions m/z 419 → 270 and 304 → 260 for the analyte and IS, resp., and 100 ms integration time, the method detection and quantification limits 12 ng g-1 and 40 ng g-1 of Cr (as CrPic3) in the air-dried powder. Acetonitrile extracts of the real-world samples presented varying from sample-to-sample chem. composition and IS efficiently compensated for ionization interferences. Mean results from triplicate anal. of four different supplements were obtained with relative standard deviation 0.1-4.0%, indicating acceptable precision. Trueness of the proposed FIA-ESI-ITMS/MS procedure was demonstrated by 95.8-108% percentage recoveries attained in the anal. of the CrPic3-spiked samples. For comparative purposes, total Cr was determined by ICP-MS. The quant. results obtained indicate the necessity of anal. control of Cr(III) supplements com. available and demonstrate that the proposed FIA-ESI-ITMS/MS procedure is well-suited for the determination of CrPic3 in such products. After reading the article, we found that the author used Picolinic acid(cas: 98-98-6Application In Synthesis of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Application In Synthesis of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reina, Miguel; Hernandez-Ayala, Luis Felipe; Bravo-Gomez, Maria Elena; Gomez, Virginia; Ruiz-Azuara, Lena published their research in Inorganica Chimica Acta in 2021. The article was titled 《Second generation of Casiopeinas: A joint experimental and theoretical study》.Recommanded Product: 1134-35-6 The article contains the following contents:

Herein, we present the synthesis, characterization, DFT calculations and in vitro evaluation of antiproliferative activity against HeLa and MCF-7 cancer tumor cell lines of three novel second generation Casiopeinas complexes. These compounds are characterized by the substitution of the usual neg. charged secondary ligand with a neutral bidentate ligand (2AMB = 2-aminomethylbenzimidazole), in order to improve both hydrophilicity and antiproliferative activity. Geometry for the compounds in this study assumes that complexes present a five-coordination number with a square pyramidal geometry, in which two bidentate ligands are in the plane and a nitrate anion is bonded in the axial position. Among analyzed complexes, only [Cu(4,7-dimethyl-1,10-phenanthroline)(2AMB)(NO3)]NO3 (1) is shown to be more effective than the referenced cisplatin drug, against both HeLa and MCF-7 tumor cell lines. Finally, for studied compounds, structure-activity relationships are strongly determined by either the calculated molar volume (V) or the redox potential (E1/2) of CuII/CuI of the complexes. These results aim to encourage further joint exptl. theor. studies, not only to describe biol. activity, but also to predict it. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Recommanded Product: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rathnayake, Manjula D.; Weaver, Jimmie D. III published their research in Organic Letters in 2021. The article was titled 《Coupling Photocatalysis and Substitution Chemistry to Expand and Normalize Redox-Active Halides》.Product Details of 100-48-1 The article contains the following contents:

Photocatalysis can generate radicals in a controlled fashion and has become an important synthetic strategy. However, limitations due to the reducibility of alkyl halides prevent their broader implementation. Herein authors explore the use of nucleophiles that can substitute the halide and serve as an electron capture motif that normalize the variable redox potentials across substrates. When used with photocatalysis, bench-stable, com. available collidinium salts prove to be excellent radical precursors with a broad scope. The results came from multiple reactions, including the reaction of 4-Cyanopyridine(cas: 100-48-1Product Details of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bhowmick, Indrani; Newell, Brian S.; Shores, Matthew P. published their research in Dalton Transactions in 2021. The article was titled 《A systematic study of the influence of ligand field on the slow magnetic dynamics of Co(II)-diimine compounds》.Synthetic Route of C12H12N2 The article contains the following contents:

Herein the authors report heteroleptic Co(II) diimine complexes [Co(H2bip)2Cl2] (1), [Co(H2bip)2Br2] (2), [Co(H2bip)3]Br2·MeOH (3) and [Co(H2bip)2(Me2bpy)]Br2·(MeCN)0.5·(H2O)0.25 (4) (H2bip = 2,2′-bi-1,4,5,6-tetrahydropyrimidine, bpy = 2,2′-dipyridyl, Me2bpy = 4,4′-Me-2,2′-dipyridyl), purposefully prepared to enable a systematic study of magnetic property changes arising from the increase of overall ligand field from σ/π-donor chlorido in 1 to π-acceptor 4,4’Me-2,2’bpy in 4. The axial and rhombic anisotropy (D and E) of these compounds is sufficient to allow 1-4 to show field-induced slow relaxation of magnetization. The authors found as the effective ligand field is increased in the series, rhombicity (E/D) decreases, and the magnetic relaxation profile changes significantly, where relaxation of magnetization at a specific temperature becomes gradually faster. The authors performed mechanistic analyses of the temperature dependence of magnetic relaxation times considering Orbach relaxation processes, Raman-like relaxation and quantum tunnelling of magnetization (QTM). The effective energy barrier of the Orbach relaxation process (Ueff) is largest in 1 (19.2 cm-1) and gradually decreases in the order 1 > 2 > 3 > 4 giving a min. value in 4 (8.3 cm-1), where the Raman-like mechanism showed the possibility of different types of phonon activity below and above ~2.5 K. As a precursor of 1, the tetrahedral complex [Co(H2bip)Cl2] (1a) was also synthesized and structurally and magnetically characterized. 1A exhibits slow relaxation of magnetization under an applied d.c. field (1800 Oe) with a record slow relaxation time of 3.39 s at 1.8 K. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Synthetic Route of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Synthetic Route of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Weiwei; Li, Ruihua; Deng, Fei; Yan, Chunyu; Zhou, Xuelian; Miao, Lu; Li, Xiaolian; Xu, Zhaochao published their research in ACS Applied Bio Materials in 2021. The article was titled 《A Cell Membrane Fluorogenic Probe for Gram-Positive Bacteria Imaging and Real-Time Tracking of Bacterial Viability》.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine The article contains the following contents:

Bacterial infections are a global healthcare problem, resulting in serious clin. morbidities and mortality. Real-time monitoring of live bacteria by fluorescent imaging technol. has potential in diagnosis of bacterial infections, elucidating antimicrobial agents′ mode of action, assessing drug toxicity, and examining bacterial antimicrobial resistance. A naphthalimide-derived fluorescent probe ZTRS-BP was developed for wash-free Gram-pos. bacteria imaging. The probe aggregated in aqueous solutions and exhibited aggregation-caused fluorescence quenching (ACQ). The interaction with Gram-pos. bacteria cell walls would selectively disaggregate the probe and the liberated probes were dispersed on the outside of the bacteria cell walls to achieve surface fluorescence imaging. There were no such interactions with Gram-neg. bacteria, which indicates that selective binding and imaging of Gram-pos. bacteria was achieved. The binding of zinc ions by ZTRS-BP can enhance the fluorescent signals on the bacterial surface by inhibiting the process of photoinduced electron transfer. ZTRS-BP-Zn(II) complex was an excellent dye to discriminate mixed Gram-pos. and Gram-neg. bacteria. Also, live and dead bacteria can be differentially imaged by ZTRS-BP-Zn(II). Furthermore, ZTRS-BP-Zn(II) was used for real-time monitoring bacteria viability such as B. cereus treated with antibiotic vancomycin. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine) was used in this study.

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yuan, Lei; Gao, Hongshuai; Jiang, Haiyan; Zeng, Shaojuan; Li, Tao; Ren, Baozeng; Zhang, Xiangping published their research in Journal of Molecular Liquids in 2021. The article was titled 《Experimental and thermodynamic analysis of NH3 absorption in dual-functionalized pyridinium-based ionic liquids》.Related Products of 103-74-2 The article contains the following contents:

A novel type of dual-functionalized pyridinium-based ionic liquids (ILs) with acidic protons and hydroxyl groups, were designed and synthesized for ammonia (NH3) absorption. The NH3 absorption isotherms in dualfunctionalized pyridinium-based ILs at temperatures from 303.15 to 343.15 K and pressures up to 600 kPa were computed using gas-liquid equilibrium method. It revealed that 4-pyridinemethanol bis (trifluoromethane)sulfonamide [4-MeOHPy][NTf2] showed the maximum NH3 solubility of 3.43 mol NH3/mol IL at 313.15 K and atm. pressure, surpassing any nonmetallic ILs previously reported. Furthermore, the characteristics of isotherms under low pressures behaved an obvious chem. reaction between ILs and NH3, and all exptl. solubilities were regulated by a reaction equilibrium thermodn. model (RETM). The thermodn. properties were further obtained to better understand the NH3 absorption process. The results indicated that this model endorses the 1:1 (NH3-IL) mole ratio of chem. reaction mechanism and the reaction enthalpy is main driving force of NH3 absorption in ILs. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Related Products of 103-74-2)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Related Products of 103-74-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Encapsulation of Phosphorescent Pt(II) Complexes in Zn-Based Metal-Organic Frameworks toward Oxygen-Sensing Porous Materials》 was written by Knedel, Tim-Oliver; Buss, Stefan; Maisuls, Ivan; Daniliuc, Constantin G.; Schluesener, Carsten; Brandt, Philipp; Weingart, Oliver; Vollrath, Annette; Janiak, Christoph; Strassert, Cristian A.. Name: 2,6-Dibromopyridine And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

In this work, two tailored phosphorescent Pt(II) complexes are synthesized bearing a cyclometalating tridentate thiazole-based C^N*N pincer luminophore (L) and exchangeable chlorido ([PtCl(L)]) or cyanido ([PtCN(L)]) coligands. While both complexes showed photoluminescence from metal-perturbed ligand-centered triplet states (3MP-LC), [PtCN(L)] reached the highest phosphorescence quantum yields and displayed a significant sensitivity toward quenching by 3O2. They were encapsulated into two Zn-based metal-organic frameworks, namely, MOF-5 and ZIF-8. The incorporation of the organometallic compounds in the resulting composites [PtCl(L)]@ZIF-8, [PtCN(L)]@ZIF-8, [PtCl(L)]@MOF-5 and [PtCN(L)]@MOF-5 was verified by powder X-ray diffractometry, SEM, time-resolved photoluminescence spectroscopy and microscopy, as well as N2- and Ar-gas sorption studies. The amount of encapsulated complex was determined by graphite furnace at. absorption spectroscopy, showing a maximum loading of 3.7 wt %. If compared with their solid state forms, the solid-solution composites showed prolonged 3O2-sensitive excited state lifetimes for the complexes at room temperature, reaching up to 18.4μs under an Ar atm., which is comparable with the behavior of the complex in liquid solutions or even frozen glassy matrixes at 77 K. Two tailored phosphorescent Pt(II) complexes were synthesized bearing a cyclometalating tridentate thiazole-based C^N*N pincer luminophore and exchangeable coligands. They were encapsulated into two Zn-based metal-organic frameworks, namely, MOF-5 and ZIF-8. If compared with their liquid solutions, the solid-solution composites showed prolonged 3O2-sensitive excited state lifetimes for the complexes at room temperature, reaching up to 18.4μs under an Ar atm., which is comparable with the behavior of the complex in frozen glassy matrixes at 77 K.2,6-Dibromopyridine(cas: 626-05-1Name: 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Name: 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones》 was written by Wang, Hua; Liu, Jie; Qu, Jian-Ping; Kang, Yan-Biao. Formula: C7H7NO And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An organocatalyzed aerobic benzylic C-H oxidation of alkyl and aryl heterocycles has been developed. This transition metal-free method is able to overcome the electron-withdrawing effect as well as product-inhibition effects in heterobenzylic radical oxidation A variety of ketones bearing N-heterocyclic groups could be prepared under relatively mild conditions with moderate to high yields. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Iron-cobalt-catalyzed heterotrimerization of alkynes and nitriles to polyfunctionalized pyridines》 was written by Xie, Yufang; Wu, Chengjuan; Jia, Changhao; Tung, Chen-Ho; Wang, Wenguang. Related Products of 100-48-1 And the article was included in Organic Chemistry Frontiers in 2020. The article conveys some information:

Based on the reactivity of half-sandwich complexes [Cp*Fe(NCMe)3]PF6 and Cp*Co(1,2-Ph2PC6H4NH), (Cp* = Me5C5-), the iron(II)-cobalt(II) co-catalysis of the cycloaddition of alkynes to nitriles under mild reaction conditions was studied. This method enabled the synthesis of polysubstituted pyridines in a single step and especially valuable for the preparation of 2,3,4,5,6-pentafunctionalized pyridines. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Related Products of 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem