Category: pyridine-derivatives

《Water-soluble copper(II) complexes with 4,5-dichloro-isothiazole-3-carboxylic acid and heterocyclic N-donor ligands: Synthesis, crystal structures, cytotoxicity, and DNA binding study》 was published in Inorganica Chimica Acta in 2020. These research results belong to Eremina, Julia A.; Lider, Elizaveta V.; Sukhikh, Taisiya S.; Klyushova, Lyubov S.; Perepechaeva, Maria L.; Sheven’, Dmitriy G.; Berezin, Alexey S.; Grishanova, Alevtina Y.; Potkin, Vladimir I.. Product Details of 1134-35-6 The article mentions the following:

Mixed-ligand copper(II) complexes based on 1,10-phenanthroline and related compounds are of interest to scientists due to their promising anticancer properties. In this study, four new water-soluble copper(II) complexes [Cu(dmbipy)L2], [Cu(phen)(H2O)L2], [Cu(dmphen)L2] and [Cu2(bipy)2L4], where HL – 4,5-dichloro-isothiazole-3-carboxylic acid, bipy = 2,2′-bipyridine, dmbipy = 2,2′-bi-4-picoline, phen = 1,10-phenanthroline, dmphen = 4,7-dimethyl-1,10-phenanthroline are reported. All complexes have been characterized by elemental and powder x-ray diffraction anal., EPR and IR-spectroscopy. Mol. structures of the reported complexes have been determined by single crystal x-ray diffraction. Copper(II) ion, HL and heterocyclic N-donor ligands have been found to form 1:2:1 complexes that possess square bipyramid or square pyramidal geometry. The UV-vis spectroscopy and mass spectrometry have been applied to show the behavior of the compounds in solution All complexes have been screened in vitro for their cytotoxic activity against Hep-2 and MCF-7 cell lines. They exhibit significant dose-dependent cytotoxic effect and [Cu(dmphen)L2] is the most cytotoxic (IC50 = 0.97 ± 0.03μM when compared to IC50 = 9.2 ± 0.5μM for control, cisplatin – Hep-2 cell line). The investigation of DNA binding ability by UV-vis titration technique indicates that complexes obtained exhibit moderate binding affinity toward calf thymus DNA. Effect of [Cu(dmbipy)L2] and [Cu(dmphen)L2] on activity of drug-metabolizing enzymes cytochromes P 450 has also been investigated. The addition of complexes to the hepatic microsomes of 3-MC or PB-treated rat, lead to a dose-dependent decrease of CYP’s activities. The data obtained indicate that [Cu(dmphen)L2] and [Cu(phen)(H2O)L2] can be potential anticancer agents. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Product Details of 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Product Details of 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of 2-Arylpyridines and 2-Arylbipyridines via Photoredox-Induced Meerwein Arylation with in Situ Diazotization of Anilines》 was published in Journal of Organic Chemistry in 2020. These research results belong to Hagui, Wided; Soule, Jean-Francois. Computed Properties of C7H7NO The article mentions the following:

Herein a sustainable method for the preparation of 2-arylpyridines through C-H arylation of pyridines using in situ formed diazonium salts (from com. available aromatic amines) in the presence of a photoredox catalyst under blue light-emitting diode (LED) irradiation The reaction is tolerant to a wide range of functional groups (e.g., halogen, nitrile, formyl, acetyl, ester). Applications to the C-H bond arylation of bipyridine ligands is also presented. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Copper-Catalyzed C-4 Carboxylation of 1-Naphthylamide Derivatives with CBr4/MeOH》 were Sahoo, Tapan; Sen, Chiranjit; Singh, Harshvardhan; Suresh, E.; Ghosh, Subhash Chandra. And the article was published in Advanced Synthesis & Catalysis in 2019. Recommanded Product: Picolinic acid The author mentioned the following in the article:

A copper catalyzed C-4 carboxylation reaction of 1-naphthylamide derivatives using carbon tetra bromide and methanol was reported to get corresponding ester derivatives e.g., I. Picolinamide and its derivatives were used as a bidentate directing group for the distal C4-H functionalization. Various substituted naphthylamide derivatives, and anilides were employed for the carboxylation and proceeds in good yields under mild condition. From the outcome of exptl. results, it was proposed that C4-H carboxylation reaction of 1-naphthylamides might proceed through a single electron transfer pathway. In the experimental materials used by the author, we found Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Mechanochemistry, an Easy Technique to Boost the Synthesis of CuI Pyrazine Coordination Polymers》 were Cappuccino, Chiara; Farinella, Francesco; Braga, Dario; Maini, Lucia. And the article was published in Crystal Growth & Design in 2019. SDS of cas: 100-48-1 The author mentioned the following in the article:

Depending on the exptl. conditions, the solid-state reactions of CuI with pyrazine (pyz) yield three distinct coordination polymers (CPs): a double chain polymer [Cu2I2(pyz)]n (yellow powder) and a single strand [CuI(pyz)]n (red powder) and its new isomeric compound [(CuI)2(pyz)2]n (orange powder), which present dimers of CuI bridged by the pyrazine ligands. The conversions among the three CPs were studied: by heating to 110°, [CuI(pyz)]n or [(CuI)2(pyz)2]n convert into [Cu2I2(pyz)]n, which reverts to the starting compounds upon kneading or grinding in the presence of pyrazine. The orange isomer [(CuI)2(pyz)2]n is obtained only when the solid-state reaction is performed with neat grinding or by direct melting of the pyrazine; it is unstable in the presence of solvent or vapor, and it readily transforms into the red isomer. The structure of [(CuI)2(pyz)2]n was determined by x-ray powder diffraction. [Cu2I2(pyz)]n reacts also with 4-cyanopyrazine to yield the mixed ligand compound [(CuI)(4CN-py)2 py]n, which, when heated, decomposes into [Cu2I2(pyz)]n and [(CuI)4(4CN-py)5]n. In the experiment, the researchers used 4-Cyanopyridine(cas: 100-48-1SDS of cas: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.SDS of cas: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemistry of Materials included an article by Meier, Christian B.; Clowes, Rob; Berardo, Enrico; Jelfs, Kim E.; Zwijnenburg, Martijn A.; Sprick, Reiner Sebastian; Cooper, Andrew I.. Recommanded Product: 2,5-Dibromopyridine. The article was titled 《Structurally diverse covalent triazine-based framework materials for photocatalytic hydrogen evolution from water》. The information in the text is summarized as follows:

A structurally diverse family of 39 covalent triazine-based framework materials (CTFs) are synthesized by Suzuki-Miyaura polycondensation and tested as hydrogen evolution photocatalysts using a high-throughput workflow. The two best-performing CTFs are based on benzonitrile and dibenzo[b,d]thiophene sulfone linkers, resp., with catalytic activities that are among the highest for this material class. The activities of the different CTFs are rationalized in terms of four variables: the predicted electron affinity, the predicted ionization potential, the optical gap, and the dispersibility of the CTFs particles in solution, as measured by optical transmittance. The electron affinity and dispersibility in solution are found to be the best predictors of photocatalytic hydrogen evolution activity. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Recommanded Product: 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Advanced Synthesis & Catalysis included an article by Li, Lixin; Ma, Yan-Na; Tang, Mi; Guo, Jing; Yang, Zhen; Yan, Yizhe; Ma, Xiantao; Tang, Lin. Electric Literature of C33H24IrN3. The article was titled 《Photoredox-Catalyzed Oxydifluoroalkylation of Styrenes for Access to Difluorinated Ketones with DMSO as an Oxidant》. The information in the text is summarized as follows:

By taking advantage of DMSO (DMSO) as an oxidant, the photoredox-catalyzed alkene oxydifluoroalkylation for formal C(sp3)-CF2R and C(sp2)=O formation is disclosed for the first time. This difunctionalization reaction employs readily available styrenes as the substrates and bromodifluoro compounds as the difluoroalkylating reagents, which can afford the difluorinated ketones in acceptable yields with excellent regioselectivity. Experiments indicate that fac-Ir(ppy)3-catalyzed oxydifluoroalkylation can proceed smoothly under base-free conditions in the presence of AgTFA. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Electric Literature of C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Journal of Medicinal Chemistry included an article by Zhao, Chao; Huang, Dane; Li, Ruyue; Xu, Yida; Su, Shimin; Gu, Qiong; Xu, Jun. Recommanded Product: 2510-22-7. The article was titled 《Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach》. The information in the text is summarized as follows:

In this paper, we applied a chemotype-assembly approach for ligand-based drug discovery (LBDD) to discover novel anti-osteoporosis leads. With this new approach, we identified 12 chemotypes and derived 18 major chemotype assembly rules from 245 known anti-osteoporosis compounds Then, we selected 19 compounds from an inhouse compound library using chemotype-assembly approach for anti-osteoporosis assays, which resulted in 13 hits. Based on structural features in these 13 compounds, we synthesized 50 possible anti-osteoporosis compounds from the anti-osteoporosis chemotypes by means of click chem. techniques and discovered a compound (10a, IC50 = 2 nM) with nanomolar activity. Compound 10a was then proved to be an anti-osteoporosis lead since it can prevent bone loss in vivo. After reading the article, we found that the author used 4-Ethynylpyridine(cas: 2510-22-7Recommanded Product: 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Recommanded Product: 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2018,Mikhailine, Alexandre A.; Grasa Mannino, Gabriela A.; Colacot, Thomas J. published 《Catalyst-Directed Chemoselective Double Amination of Bromo-chloro(hetero)arenes: A Synthetic Route toward Advanced Amino-aniline Intermediates》.Organic Letters published the findings.COA of Formula: C5H3BrClN The information in the text is summarized as follows:

A chemoselective sequential one-pot coupling protocol was developed for preparing several amino-anilines in high yield as building blocks for active pharmaceutical ingredients (APIs). Site (Cl vs Br on electrophile) and nucleophile (amine vs imine) selectivity is dictated by the catalyst employed. A Pd-crotyl(t-BuXPhos) precatalyst selectively coupled the Ar-Br of the polyhaloarene with benzophenone imine, even in the presence of a secondary amine, while Pd-based RuPhos or (BINAP)Pd(allyl)Cl coupled the Ar-Cl site with secondary amines. In the experimental materials used by the author, we found 5-Bromo-2-chloropyridine(cas: 53939-30-3COA of Formula: C5H3BrClN)

5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.COA of Formula: C5H3BrClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Kai; Zhou, Zhiming; Song, Jinhong; Bi, Lixue; Shen, Ning; Wu, Yukai; Chen, Fuxue; Wen, Hongliang published their research in Journal of Hazardous Materials on December 15 ,2010. The article was titled 《A metal-free aerobic oxidation of nitrotoluenes catalyzed by N,N’,N”-trihydroxyisocyanuric acid (THICA) and a novel approach to the catalyst》.Safety of 3-Nitroisonicotinic acid The article contains the following contents:

A metal-free catalytic system with N,N’,N”-trihydroxyisocyanuric acid (THICA) as the catalyst for the oxidation of nitrotoluenes is introduced, and a novel Pd-free approach for the synthesis of THICA was developed. In a solution of acetic acid, THICA and concentrated nitric acid, nitrotoluenes especially polynitrotoluenes such as 2,4,6-trinitrotoluene (TNT), were converted into the desired carboxylic acids under 0.2 MPa of O2 at 100 °C with yields up to 99%. THICA was synthesized from N-hydroxyphtalimide through a four-step synthesis in a total yield of 46%. A possible mechanism of this catalytic process was proposed where NO2 and nitric acid first induced a radical of THICA, which then abstracts a hydrogen atom from the Me on the aromatic ring to form a benzyl radical. This radical then initiates subsequent reactions. The production of the benzyl radical was supported by ESR measurements. In the experimental materials used by the author, we found 3-Nitroisonicotinic acid(cas: 59290-82-3Safety of 3-Nitroisonicotinic acid)

3-Nitroisonicotinic acid(cas: 59290-82-3) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Safety of 3-Nitroisonicotinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Santos, Jonnatan J.; Toma, Sergio H.; Monezi, Natalia M.; Ando, Romulo A.; Corio, Paola; Araki, Koiti published their research in Inorganic Chemistry on August 5 ,2019. The article was titled 《Selecting the Mechanism of Surface-Enhanced Raman Scattering Effect using Shell Isolated Nanoparticles and an Oxo-Triruthenium Acetate Cluster Complex》.Recommanded Product: 112881-51-3 The article contains the following contents:

After >40 years, surface-enhanced Raman spectroscopy (SERS) stills attract much attention from chemists, not only because of the synthesis of plasmonic nanostructures but also due to the several simultaneous mechanisms which still remain unclear. One of the possibilities for a better understanding of the SERS mechanisms is the use of suitable inorganic complexes. The use of inorganic complexes makes it possible to observe the 2 main SERS mechanisms (electromagnetic and chem.) and to observe the intensification of Raman scattering due to the resonance Raman effect. The observation of these mechanisms was possible using an unpublished and interesting complex with 2 oxo-triruthenium acetate clusters and an Fe bis(terpyridine) in its structure (7 metals) and which interacted with bare Au nanoparticles and shell-isolated Au nanoparticles (SHIN), with a 1 nm SiO2 shell. The use of SHIN allowed quenching the SERS chem. mechanism and led to a spectrum where Fe-terpyridine peaks are absent and only the modes related to [Ru3O] center were observed (due to enhancement by resonance Raman, SERRS); it can be said that the shell-isolated nanoparticles enhanced resonance Raman spectroscopy (SHINERRS) is observed This approach led to a perfect selection of SERS mechanisms never seen before with any other mol./complex. As can be seen in the UV-visible spectrum, this complex has a strong band around 700 nm, which suggests that SiO2 shell enhances only surface-enhanced resonance Raman scattering, a long-distance phenomenon, different from chem. enhancement (a short-distance phenomenon). Along with the Raman spectroscopy results, cyclic voltammetry, UV-visible spectroelectrochem., resonance Raman (using 568 and 676 nm lasers), and d. functional theory calculations of this new Ru cluster are presented. The experimental part of the paper was very detailed, including the reaction process of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Recommanded Product: 112881-51-3)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Recommanded Product: 112881-51-3The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem