Category: pyridine-derivatives

《Zn(II) and Cd(II) monomer, dimer and polymer compounds coordinated by benzoic acid and 4-acetylpyridine: Synthesis and crystal structures》 was written by Moreno-Gomez, Laura; Sanchez-Ferez, Francisco; Calvet, Teresa; Font-Bardia, Merce; Pons, Josefina. SDS of cas: 1122-54-9This research focused onzinc cadmium benzoate acetylpyridine complex preparation fluorescence; crystal structure zinc cadmium benzoate acetylpyridine. The article conveys some information:

Reaction of MO (MO = Metal oxide, M = Zn(II) or Cd(II)) with benzoic acid (HBz) in H2O/MeOH mixture as solvent yields two benzoate compounds: [Zn(μ-Bz)2]n (1) and [Cd(Bz)2(H2O)3] (2). In addition, the reaction between M(MeCO2)2 (M = Zn(II) or Cd(II)) with HBz and 4-acetylpyridine (4-Acpy) in a 1:2:4 M ratio and in MeOH solution, leads to the formation of [Zn(μ-Bz)2(4-Acpy)]2 (3) and [Cd(μ-Bz)2(4-Acpy)2]2 (4). These four compounds have been fully characterized by anal. and spectroscopic techniques. Besides, their crystal structures have been elucidated revealing a 1D coordination polymer (1), a monomer (2), a paddle-wheel (3) and a dimer (4). In 1, the Zn(II) ion is four-coordinated in a tetrahedral geometry while in 3 is penta-coordinated in a square-pyramidal geometry. By contrast, compounds 2 and 4 exhibit seven-coordinated Cd(II) ions in a pentagonal-bipyramidal geometry. In these set of compounds, the benzoate ligand presents different coordination modes such as bidentate bridged (μ2-η1:η1) (1 and 3), chelate (μ1-η2) (2) and both bridged and chelate (μ2-η2:η1) (4). Besides, their extended structures have been analyzed. Finally, the UV-Vis and fluorescence spectra of all the compounds have been recorded as well as their quantum yields calculated4-Acetylpyridine(cas: 1122-54-9SDS of cas: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Transition-metal-free direct nucleophilic substitution of carboranyllithium and 2-halopyridines》 was written by Lu, Ju-You; Zhao, Bo; Du, Yongmei; Yang, Jianxin; Lu, Jian. Electric Literature of C6H6BrNThis research focused ontransition metal free nucleophilic substitution carboranyl lithium halopyridine; pyridinyl carborane preparation. The article conveys some information:

A practical and efficient C(cage)-heteroarylation of carborane is presented, via direct nucleophilic substitution of carboranyllithium with 2-halopyridines. This reaction does not need the aid of any transition metal and utilizes readily available carboranyllithium nucleophiles, thereby avoiding transmetalation of carboranyllithium. The process exhibits a broad scope, and a vast array of 2-halopyridines have proven to be suitable substrates. The method serves as a complement to C(cage)-arylation reactions and may find wide applications in materials science and medicinal and coordination chem. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C12H12N2In 2021 ,《A straightforward synthesis of neutral hexacoordinated silicon(IV) complexes with SiN6 skeleton》 was published in Inorganica Chimica Acta. The article was written by Cruz-Lopez, Juan F.; Palacios-Chavez, Jesus A.; Guajardo-Garcia, Joel A.; Gonzalez-Garcia, Andres; Baez, Jose E.; Lopez, Jorge A.; Orozco-Castellanos, Luis M.; Gonzalez-Garcia, Gerardo. The article contains the following contents:

Three neutral hexacoordinate silicon(IV) complexes with SiN6 skeleton were obtained via one-pot synthesis by using tetra(thiocyanato-N)silane, Si(NCS)4 with an equimolar amount of 2,2′-bipyridyl (bipy), 4,4′-dimethyl-2,2′-dipyridyl (dmp) and 1,10-phenanthroline (phen) resp. The complexes obtained; (bipy)Si(NCS)4 (1), (dmp)Si(NCS)4 (2), and (phen)Si(NCS)4 (3) belong to a family of neutral hexacoordinate silicon(IV) with SiN6 coordinating framework, which has been less studied both by single-crystal x-ray diffraction and 29Si NMR spectroscopies. All the complexes were characterized by single-crystal x-ray diffraction, solution 1H, 13C{H}, 29Si, solid-state 29Si CP/MAS NMR spectroscopies, and elemental anal. was used to confirm the structures. Comparison of the 29Si chem. shieldings of the complexes 1-3 in the solution and solid-state indicated that all complexes maintain the hexacoordination at silicon atom in DMSO-D6 solution This works demonstrated the synthetic potential of Si(NCS)4 for the synthesis of new neutral hexacoordinate silicon complexes with SiN6 skeleton via one-pot synthesis. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1122-54-9In 2020 ,《Synthesis of selective bioactive pyridylpyridones: in silico studies and biological evaluations》 appeared in Asian Journal of Chemistry. The author of the article were Ramasamy, Suresh; Ponnuchamy, Singanan; Ponnusamy, Sivakumar. The article conveys some information:

Twenty three substituted pyridylpyridones I (X = CH, N; Y = N, CH; R = H, 2,5-F2, 4-Cl, 4-OMe, etc.) were designed and performed for mol. docking studies against α-amylase enzyme. Exptl. biol. applications were studied for the top three hit compounds (X = N, Y = CH, R = 2-Cl; X = CH, Y = N, R = H; X = CH, Y = N, R = 2,5-F2). The DFT calculations were executed for the hit compounds In addition, mol. electrostatic potential mapping was also executed for addnl. support. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1122-54-9In 2021 ,《3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo》 appeared in Journal of Medicinal Chemistry. The author of the article were Dayal, Neetu; Reznickova, Eva; Hernandez, Delmis E.; Perina, Miroslav; Torregrosa-Allen, Sandra; Elzey, Bennett D.; Skerlova, Jana; Ajani, Haresh; Djukic, Stefan; Vojackova, Veronika; Lepsik, Martin; Rezacova, Pavlina; Krystof, Vladimir; Jorda, Radek; Sintim, Herman O.. The article conveys some information:

Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds e.g., I were rapidly assembled via the Doebner-Povarov multicomponent reaction from the readily available 5-aminoindazoles, ketones and aldehydes in good yields. The most active compounds potently inhibit the recombinant FLT3 kinase and its mutant forms with nanomolar IC50 values. Docking studies with the FLT3 kinase showed a type I binding mode, where the 3H-pyrazolo group interacts with Cys694 in the hinge region. The compounds blocked the proliferation of AML cell lines harboring oncogenic FLT3-ITD mutations with remarkable IC50 values, which were comparable to the approved FLT3 inhibitor quizartinib. The compounds also inhibited the growth of leukemia in a mouse-disseminated AML model, and hence, the novel 3H-pyrazolo[4,3-f]quinoline-containing kinase inhibitors are potential lead compounds to develop into anticancer agents, especially for kinase-driven cancers. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Picolinic acidIn 2019 ,《Detection of Purine Metabolite Uric Acid with Picolinic-Acid-Functionalized Metal-Organic Frameworks》 appeared in ACS Applied Materials & Interfaces. The author of the article were Qu, Shumei; Li, Zheng; Jia, Qiong. The article conveys some information:

Uric acid (UA) is a purine metabolite closely related to the metabolic function of human. Fluorescence anal. is a very effective method because of high selectivity and sensitivity but still remains a great challenge for direct UA detection. In this work, a fluorescent sensor based on postfunctionalized metal organic framework (UiO-PSM) was designed focusing on the direct detection of UA. UiO-PSM was synthesized from a zirconium-based MOF (UiO-66-NH2) and 2-picolinic acid (PA) through an amidation reaction. Because UA could quench the fluorescence of UiO-PSM through coordination, hydrogen bonding, and π-π interactions, the sensor could detect UA directly. UiO-PSM exhibited the advantages of short reaction time, high selectivity, high sensitivity, and wide linear range for UA detection. This work provided a novel method for UA detection and had potential application value in clin. diagnosis. The experimental part of the paper was very detailed, including the reaction process of Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 6-Bromopyridin-3-amineIn 2010 ,《Catalytic Chain-Breaking Pyridinol Antioxidants》 appeared in Journal of Organic Chemistry. The author of the article were Kumar, Sangit; Johansson, Henrik; Kanda, Takahiro; Engman, Lars; Muller, Thomas; Bergenudd, Helena; Jonsson, Mats; Pedulli, Gian Franco; Amorati, Riccardo; Valgimigli, Luca. The article conveys some information:

The synthesis of 3-pyridinols carrying alkyltelluro, alkylseleno, and alkylthio groups is described together with a detailed kinetic, thermodn., and mechanistic study of their antioxidant activity. When assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system, tellurium-containing 3-pyridinols were readily regenerable by N-acetylcysteine contained in the aqueous phase. The best inhibitors quenched peroxyl radicals more efficiently than α-tocopherol, and the duration of inhibition was limited only by the availability of the thiol reducing agent. In homogeneous phase, inhibition of styrene autoxidation absolute rate constants kinh for quenching of peroxyl radical were as large as 1 × 107 M-1/s-1, thus outperforming the best phenolic antioxidants including α-tocopherol. Tellurium-containing 3-pyridinols could be quant. regenerated in homogeneous phase by N-tert-butoxycarbonyl cysteine Me ester, a lipid-soluble analog of N-acetylcysteine. In the presence of an excess of the thiol, a catalytic mode of action was observed, similar to the one in the two-phase system. Overall, compounds bearing the alkyltelluro moiety ortho to the OH group were much more effective antioxidants than the corresponding para isomers. The origin of the high reactivity of these compounds was explored using pulse-radiolysis thermodn. measurements, and a mechanism for their unusual antioxidant activity was proposed. The tellurium-containing 3-pyridinols were also found to catalyze reduction of hydrogen peroxide in the presence of thiol reducing agents, thereby acting as multifunctional (preventive and chain-breaking) catalytic antioxidants. In the experiment, the researchers used 6-Bromopyridin-3-amine(cas: 13534-97-9Quality Control of 6-Bromopyridin-3-amine)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Quality Control of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Sayin, Koray; Rezaeivala, Majid; Erkan, Sultan; Guney, Elif published an article in Journal of Molecular Structure. The title of the article was 《Determination of structural, spectral, computational and OLED properties of Ex2.2Box2+ Cyclophane and its derivatives: Experimental and computational study》.Formula: C7H5N The author mentioned the following in the article:

Ex2.2Box2+ Cyclophane was synthesized and spectral characterization of this compound was completed by using 1H, 13CNMR, and ESI-MS spectroscopy. Furthermore, this compound and its seven derivatives were investigated by computational analyses. Initially, they were optimized at B3LYP/6-31G(d) level in the gas phase and water; then, IR and NMR spectra were analyzed. Especially, exptl. and computational results were compared with each other in Ex2.2Box2+ Cyclophane. Computational spectral results were presented due to the good harmony between exptl. and computational results. These compounds chem. reactivity and electron mobility were investigated using a contour plot of frontier MO and mol. electrostatic potential map. Finally, the OLED properties were examined, and it was found that three of the compounds were suitable candidates for OLED applications. In the part of experimental materials, we found many familiar compounds, such as 4-Ethynylpyridine(cas: 2510-22-7Formula: C7H5N)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C7H5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Shi, Zhaojiang; Lu, Hao-Kuan; Li, Nan; Yuan, Yaofeng; Li, Zhen; Ye, Ke-Yin published an article in Organic Chemistry Frontiers. The title of the article was 《Electrochemical oxidative dearomatization of 2-arylthiophenes》.SDS of cas: 197958-29-5 The author mentioned the following in the article:

A green and sustainable electrochem. oxidative dearomatization of 2-arylthiophenes was reported. The variation of substitution patterns afforded easy access to both C2/C3 and C2/C5 difunctionalized dearomative dihydrothiophenes such as I [R = Ph, 3-FC6H4, 2-pyridyl, etc.; R1 = OAc, OC(O)Et]. The synthetic utility of the resulting dihydrothiophenes was further demonstrated by the concise synthesis of a pyridazinone analog with interesting vasodilator activity. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5SDS of cas: 197958-29-5)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 197958-29-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oh, Sangmi; Kwon, Do Yoon; Choi, Inhee; Kim, Young Mi; Lee, Ji Young; Ryu, Jiyoung; Jeong, Hangyeol; Kim, Myung Jin; Song, Rita published an article in 2021. The article was titled 《Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities》, and you may find the article in ACS Medicinal Chemistry Letters.COA of Formula: C5H6BNO2 The information in the text is summarized as follows:

This study evaluated the potential use of senescence-inducing small mols. in the treatment of melanoma. We screened com. available small-mol. libraries with high-throughput screening and high-content screening image-based technol. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogs were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within. In the part of experimental materials, we found many familiar compounds, such as 2-Pyridinylboronic acid(cas: 197958-29-5COA of Formula: C5H6BNO2)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. COA of Formula: C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem