Category: pyridine-derivatives

Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco; Bartoli, Donatella; Massoli, Alberto published the artcile< The reactions of some halogenated pyridines with methoxide and methanethiolate ions in dimethylformamide>, Application of C6H6ClNO, the main research area is pyridine dihalo substitution methoxide alkanethiolate; halopyridine substitution methoxide alkanethiolate; substitution dihalopyridine methoxide alkanethiolate; mercaptopyridine; alkylthiopyridine.

Dihalopyridines I (R = 2-Br, R1 = 5-, 6-Br; R = 2-, 5-Cl, R1 = 3-Cl) reacted with NaSR2 (R2 = Me, CHMe2) in DMF to give 73-96% mono- or bis-substitution products I (R = SR2) or I (R = R1 = SR2), depending upon reaction conditions. The dihalo compounds reacted with NaOMe to give 72-93% I (R = OMe), but bis-substitution occurred easily only for I (R = 2-Br, R1 = 6-Br; R = 5-Cl, R1 = 3-Cl). Some I [R(R1) = OMe, R1(R) = SMe] were prepared by further reaction of monosubstitution products. I (R = R1 = SCHMe2 were fragmented by Na-HMPA to give I (R = R1 = SH), which were isolated as I (R = R1 = SMe) in 63-80% yield.

Tetrahedron published new progress about Nucleophilic aromatic substitution reaction. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Application of C6H6ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mihajlovic-Lalic, Ljiljana E.; Stankovic, Dalibor; Novakovic, Irena; Grguric-Sipka, Sanja published the artcile< (Electro)chemical and antimicrobial characterization of novel Ru(II) bipyridine complexes with acetylpyridine analogs>, Related Products of 350-03-8, the main research area is ruthenium bipyridine acetylpyridine complex preparation antibacterial antifungal antioxidant; DNA intercalation ruthenium bipyridine acetylpyridine complex.

Three ruthenium-bipyridine complexes (1-3) carrying acetylpyridine ligand unit were synthesized in methanol via the reaction of [RuCl2(bpy)2] with corresponding acetylpyridine (2-, 3-, and 4-acpy). Obtained complexes were characterized by (1H and 13C) NMR and IR spectroscopy, MS spectrometry, UV-visible spectrophotometry, and cyclic voltammetry. Their structural characterization revealed bidentate coordination mode for 2-acpy while 3- and 4-acpy acted as monodentate ligands. The electrochem. profile of newly synthesized compounds was studied by cyclic voltammetry which confirmed their electrochem. activity. Voltammetric responses within the -1.20 < Ep < 1.50 v range of potentials were summarized in two major events: Ru(II)→Ru(III) oxidation spotted at apparatus ΔEp = 0.65 v and successive reductions of bpy units located from -0.79 v to 0.47 v (vs. Ag/AgCl (3 M) electrode). The DNA-binding activity of the complexes was evaluated by both UV-visible spectrophotometry and cyclic voltammetry indicating DNA-intercalation with a slight contribution of electrostatic interactions. Furthermore, antimicrobial activity was tested against bacterial and fungal strains, for which moderate activity was observed Assessment of in vitro toxicity against freshly hatched nauplii of Artemia salina as well as radical scavenging capacity was evaluated. The test compounds showed neither toxicity nor antioxidant activity. Journal of Coordination Chemistry published new progress about Antibacterial agents. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Related Products of 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hsu, Day-Shin; Wang, Meng-Yu; Huang, Jiun-Yi published the artcile< Asymmetric Total Syntheses of (+)-5-epi-Schisansphenin B and the Proposed Structure of (+)-15-Hydroxyacora-4(14),8-diene>, Reference of 1416819-91-4, the main research area is Heck alkenylation Stetter Tiffeneau Demjanov enantioselective diastereoselective regioselective; epi schisansphenin B total synthesis; hydroxyacoradiene total synthesis.

The asym. total syntheses of (+)-5-epi-schisansphenin B and the proposed structure of (+)-15-hydroxyacora-4(14),8-diene have been accomplished from 1,3-cyclopentadione in eight synthetic steps. The enantioselective palladium-catalyzed redox-relay Heck alkenylation, the intramol. Stetter reaction, and the regioselective Tiffeneau-Demjanov-type ring expansion were the pivotal steps in these syntheses.

Journal of Organic Chemistry published new progress about Alkenylation, stereoselective (redox-relay Heck). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Reference of 1416819-91-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Shengrong; Chen, Ming; Cao, Xiaoqiang; Li, Guang; Zhang, Di; Li, Mingzhen; Meng, Na; Yin, Jieji; Yan, Bingqi published the artcile< Chromium (VI) removal from water using cetylpyridinium chloride (CPC)-modified montmorillonite>, Reference of 123-03-5, the main research area is chromium removal water cetylpyridinium chloride modified montmorillonite.

Montmorillonite (Mt) has been used widely for metal removal from water and wastewater due to its various advantages including low cost, large surface area, high structure stability, and high ion exchange capacity. However, the removal of anionic hexavalent chromium (Cr) using Mt is inhibited by the neg. charges on the adsorbent. To enhance Cr (VI) adsorption on Mt, a cationic surfactant – cetylpyridinium chloride (CPC) – was utilized to modify the interlayer surface of Mt. Fourier-transform IR spectroscopy and X-ray diffraction were performed to characterize the CPC modified Mt (CPC-Mt) and the structure change of Mt. Studies have shown that CPC intercalated into Mt interlayers via electrostatic interaction between Mt and CPC, as well as the hydrophobic interaction among CPC mols. After modification, the CPC-Mt showed a pos. zeta potential at pH 2-11; while the sp. surface area decreased, CPC effectively increased the interlayer distance of Ca-Mt, with a maximum d001 value of 4.37 nm, and provided more exchange sites for Cr (VI) adsorption. Cr (VI) was efficiently removed using CPC-Mt at low pH values, but the removal was influenced adversely by the increase of pH and ionic strength. The adsorption process was described by a Langmuir isotherm model with the constant of 0.342 L/mg and the maximum adsorption capacity of 43.84 mg/g at 298 K, and by a pseudo-second order kinetic model with a kinetic coefficient of 6.62 g/(mg·min). The adsorption mechanism anal. has shown that electrostatic attraction is the main mechanism for Cr (VI) removal; at the same time, the reduction of Cr (VI) to Cr (III) by Fe (II) in Mt cannot be neglected at low pH values, which increased Cr removal and was confirmed by the X-ray photoelectron spectroscopic anal.

Separation and Purification Technology published new progress about Adsorbents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Reference of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gajeles, Ghellyn; Kim, Se Mi; Yoo, Jong-Cheol; Lee, Kyung-Koo; Lee, Sang Hee published the artcile< Recyclable anhydride catalyst for H2O2 oxidation: N-oxidation of pyridine derivatives>, Category: pyridine-derivatives, the main research area is pyridine oxide green preparation; oxidation pyridine poly maleic anhydride alt octadecene catalyst.

The catalytic efficiency and recyclability of poly(maleic anhydride-alt-1-octadecene) (Od-MA) and poly(maleic anhydride-alt-1-isobutylene) (Bu-MA) were evaluated for use in the development of a metal-free, reusable catalyst for the oxidation of pyridines to pyridine N-oxides, such as I [R = 2-Cl, 3-Br, 2-CO2H, etc.] in the presence of H2O2. The Od-MA catalyst was easily recovered via filtration with recovery yields exceeding 99.8%. The catalyst retained its activity after multiple uses and did not require any treatment for reuse. The Od-MA and H2O2 catalytic system described herein was eco-friendly, operationally simple, and cost-effective; thus, it was industrially applicable. Od-MA and H2O2 could potentially be used in place of percarboxylic acid as an oxidant in a wide range of oxidation reactions.

RSC Advances published new progress about Green chemistry. 3811-73-2 belongs to class pyridine-derivatives, and the molecular formula is C5H4NNaOS, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Patel, Paresh N.; Desai, Dipen H.; Patel, Nilam C.; Deshmukh, Amar G. published the artcile< Efficient multicomponent processes for synthesis of novel poly-nuclear hetero aryl substituted terpyridine scaffolds: Single crystal XRD study>, Category: pyridine-derivatives, the main research area is naphthalenyl terpyridine preparation uv vis spectra fluorescence; benzothiophenyl terpyridine preparation; acetyl pyridine naphthaldehyde benzothiophene aldehyde multicomponent condensation reaction.

Authors studied the synthesis of novel terpyridine scaffolds from poly-nuclear and hetero-aryl aldehydes by the multicomponent condensation reactions with various acetyl pyridine derivatives in the presence of ammonium hydroxide. Comparative studies of two different processes catalyzed by potassium hydroxide and pyrrolidine have been performed and presented in this report. The structures of all the newly prepared terpyridine mols. have been well established by preforming various spectral anal. and single crystal XRD studies for selected mols. This approach addressed some structural miscellany concerns currently facing in photo-luminescent chem., and the derived hybrid pyridines could be used as suitable precursors for the synthesis of related photo-luminescent systems. The prepared scaffolds as such and their d-block or f-block metal complexes and coordination polymers may provide an efficient candidate for photo-luminescent chem.

Journal of Molecular Structure published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lamb, Claire J. C.; Vilela, Filipe; Lee, Ai-Lan published the artcile< Pd(II)-Catalyzed Enantioselective Desymmetrization of Polycyclic Cyclohexenediones: Conjugate Addition versus Oxidative Heck>, Product Details of C13H15F3N2O, the main research area is polycyclic cyclohexenedione arylboronic acid stereoselective palladium desymmetrization Heck reaction.

Pd(II)-catalyzed desymmetrization of polycyclic cyclohexenediones has been achieved with high enantio- and diastereoselectivities. Up to five contiguous stereocenters are desymmetrized, while simultaneously, an addnl. stereocenter is created by the enantioselective conjugate addition Surprisingly, the conjugate addition products dominate even under typical oxidative Heck conditions, and these observations may provide some insight into the competition between the two related reactions.

Organic Letters published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Product Details of C13H15F3N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Tan, Yee Seng; Tiekink, Edward R. T. published the artcile< Crystal structure of catena-poly{(μ2-N1,N2-bis[(pyridin-4-yl)methyl]ethanediamide-κ2N:N′)-bis(O,O′-di-isopropyldithiophosphato-κ1S)zinc(II)} - acetonitrile (1/1), C26H42N4O6P2S4Zn[n.8901]C2H3N>, Related Products of 3731-53-1, the main research area is crystal structure catenapolypyridinmethylethanediamideisopropyldithiophosphatoacetonitrile.

C28H45N5O6P2S4Zn, monoclinic, P21/c (number 14), a = 7.73670(10) Å, b = 21.56370(10) Å, c = 23.1184(2) Å, β = 99.121(1)°, V = 3808.12(6) Å3, Z = 4, Rgt(F) = 0.0210, wRref(F2) = 0.0580, T = 100(2) K. CCDC number: 1959644. The Zn[S2P(O-iPr)2]2precursor was prepared in high yield from the in situ reaction of Zn(NO3)2·6 H2O (Alfa Aesar; 14.87 g, 0.05 mol), iPrOH (Merck; 16.05 mL, 0.21 mol), P2S5(Sigma-Aldrich; 11.11 g, 0.05 mol) and 50% weight/weight NaOH solution (Merck; 8.80 mL, 0.11 mol). N, N-Bis(pyridin-4-ylmethyl) ethanediamide (4LH2) was prepared in high yield from the 2:1 reaction (reflux) of 4-picolylamine (Aldrich; 2.03 mL, 0.02 mol) and di-Et oxalate (Aldrich; 1.36 mL, 0.01 mol) in ethanol solution (Merck; 5 mL). The title compound was obtained by mixing a suspension of Zn[S2P(O-iPr)2]2(0.50 g, 1.02 mmol) and N,N-bis(pyridin-4-ylmethyl)ethanediamide (0.28 g, 1.04 mmol) in DMF (Merck; 5 mL), followed by stirring for 30 min at 373 K. The solution was filtered, the filtrate taken in acetonitrile (Merck; 1 mL) and transferred to a vial for crystallization Yellow crystals formed after one day.

Zeitschrift fuer Kristallographie – New Crystal Structures published new progress about Crystal structure. 3731-53-1 belongs to class pyridine-derivatives, and the molecular formula is C6H8N2, Related Products of 3731-53-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

He, Qiao; Guo, Mingming; Jin, Tony Z.; Arabi, Saifanassour Ali; Liu, Donghong published the artcile< Ultrasound improves the decontamination effect of thyme essential oil nanoemulsions against Escherichia coli O157: H7 on cherry tomatoes>, Electric Literature of 123-03-5, the main research area is cherry tomato Escherichia coli thyme essential oil nanoemulsion decontamination; Antibacterial activity; Cherry tomato; E. coli O157:H7; Thyme essential oil nanoemulsion; Ultrasound.

Development of novel and effective decontamination technologies to ensure the microbiol. safety of fresh produce has gained considerable attention, mainly driven by numerous outbreaks. This work presented the first approach regarding to the application of the previously reported hurdle technologies on the sanitization of artificially contaminated cherry tomatoes. Thyme (Thymus daenensis) essential oil nanoemulsion (TEON, 8.28 nm in diameter with a narrow size distribution) was formulated via ultrasonic nanoemulsification, showing remarkably improved antimicrobial activity against Escherichia coli (E. coli) O157:H7, compared to the coarse emulsion. The antimicrobial effect of ultrasound (US), thyme essential oil nanoemulsion (TEON) and the combination of both treatments was assessed against E. coli O157:H7. The remarkable synergistic effects of the combined treatments were achieved, which decontaminated the E. coli populations by 4.49-6.72 log CFU/g on the surface of cherry tomatoes, and led to a reduction of 4.48-6.94 log CFU/sample of the total inactivation. TEON combined with US were effective in reducing the presence of bacteria in wastewater, which averted the potential detrimental effect of cross-contamination resulted from washing wastewater in fresh produce industry. Moreover, the treatments did not noticeably alter the surface color and firmness of cherry tomatoes. Therefore, ultrasound combined with TEON is a promising and feasible alternative for the reduction of microbiol. contaminants, as well as retaining the quality characteristics of cherry tomatoes.

International Journal of Food Microbiology published new progress about Antimicrobial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Electric Literature of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schuster, Georg; Lindner, Wolfgang published the artcile< Comparative characterization of hydrophilic interaction liquid chromatography columns by linear solvation energy relationships>, Related Products of 21876-43-7, the main research area is hydrophilic interaction liquid chromatog column linear solvation energy relationship; acid organic hydrophilic interaction LC linear solvation energy relation; base organic hydrophilic interaction LC linear solvation energy relation.

Twenty-two com. available and home-made stationary phases with different surface modifications were compared under hydrophilic interaction liquid chromatog. (HILIC) conditions. The column set comprised neutral, basic, acidic, zwitterionic and mixed surface modifications. Retention data of 68 differently structured test solutes were acquired to generate retention models based on a linear solvation energy relation (LSER) approach. A recently modified solvation parameter model with two addnl. mol. descriptors was evaluated in terms of its universal applicability when electrostatic forces are enabled in addition to predominant partition phenomena. The suggested method could not be confirmed to be a standardized way to characterize HILIC systems when different operating conditions are applied. However, the significant contribution of the recently introduced charge descriptors (D- and D+) on explaining the interactions within HILIC systems was confirmed. The solvation parameter model is a useful tool in column development, to affirm or dismiss the preceding educated guess on how certain immobilized ligands will behave. Acidic modified surfaces (stationary phases) exhibit a very small hydrogen bond acceptor property and are less versatile when it comes to an even distribution of solutes along the retention window. Also, basic and neutral columns are more preferable for HILIC applications and might explain why only a limited variety of strong acidic modified HILIC columns, although found in literature, are available com.

Journal of Chromatography A published new progress about Electrostatic force. 21876-43-7 belongs to class pyridine-derivatives, and the molecular formula is C9H13NO3S, Related Products of 21876-43-7.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem