Category: pyridine-derivatives

Kumar, Mopidevi Manikanta; Raj, C. Retna published an article on February 22 ,2019. The article was titled 《Carbothermal-Reduction-Assisted Phosphidation of Cobalt Affords Mesoporous Nitrogen-Doped Carbon-Embedded CoP Nanoelectrocatalysts for the Oxygen Reduction Reaction》, and you may find the article in ACS Applied Nano Materials.Computed Properties of C20H14N4 The information in the text is summarized as follows:

We demonstrate a new facile single-step synthesis of mesoporous nitrogen-doped carbon-embedded cobalt phosphide (NC-CoP) nanoparticles using a single-source precursor of the cobalt(II) bis(terpyridine)-based complex ([Co(pyterpy)2](PF6)2) by carbothermal reduction Phosphidation of cobalt is achieved with the hexafluorophosphate counteranion of the precursor complex for the first time. Polypyridyl complexes such as [Co(bpy)3](PF6)2 and [Co(terpy)2](PF6)2 do not yield the desired CoP. The at. percent of carbon in the precursor complex controls the growth of CoP. The as-synthesized NC-CoP has a large surface area of 120 m2/g and shows excellent electrocatalytic activity toward the oxygen reduction reaction (ORR). It is highly durable and favors the four-electron pathway for the reduction of oxygen to water at low overpotential. The synergistic effect between NC and CoP facilitates the electron-transfer kinetics for ORR. In addition to this study using 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine, there are many other studies that have used 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Computed Properties of C20H14N4) was used in this study.

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Computed Properties of C20H14N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jia, Meng-Ze; Cui, Jing-Wang; Rao, Cai-Hui; Chen, Yun-Rui; Yao, Xin-Rong; Zhang, Jie published an article in ACS Sustainable Chemistry & Engineering. The title of the article was 《Switchable ROS Species Regulation Facilitates the Selective Oxidation of Benzyl Alcohols Enabled by an Organic Photocatalyst》.Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine The author mentioned the following in the article:

Benefiting from the regulation of ROS species through a simple and feasible strategy, an efficient and switchable photocatalytic protocol for the chemoselective synthesis of aldehydes and carboxylic acids via oxidation of primary alcs. under mild conditions was developed. Using the pyridinium derivative as a metal-free organic photocatalyst, a variety of benzyl alcs. can be converted into aldehydes or carboxylic acids under an air atm. at room temperature with high selectivity and yield via simple solvent regulation. A feasible tandem reaction combining the pyridinium-catalyzed alc.-to-aldehyde conversion and catalyst-free photoinduced oxidation of aromatic aldehydes provides a powerful and efficient approach for the one-pot oxidation of benzyl alcs. to carboxylic acids, while a small amount of water can effectively regulate the competition of electron transfer and energy transfer and inhibit the generation of carboxylic acids, facilitating highly efficient and selective oxidation of alcs. to aldehydes. In the experimental materials used by the author, we found 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Name: 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hedou, Damien; Voisin-Chiret, Anne Sophie published an article in European Journal of Organic Chemistry. The title of the article was 《Br vs. TsO Chemoselective Suzuki-Miyaura Cross-Coupling Reaction on Nicotinaldehyde Moiety for the Preparation of 2,3,5-Trisubstituted Pyridines》.Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid The author mentioned the following in the article:

Br vs. TsO chemoselective pallado-catalyzed Suzuki-Miyaura reaction has been developed from the 5-bromo-2-tosyloxynicotinaldehyde for the preparation of polysubstituted pyridines. This methodol. has been applied for the preparation of a terpyridine aldehyde, as a versatile precursor of potential Mcl-1 (Induced myeloid leukemia cell differentiation protein) inhibitors. The synthesis of pyridoclax (I), our lead compound which demonstrated efficacy for the treatment of chemoresistant ovarian cancer, has also been achieved via the palladium-catalyzed cross-coupling reaction in 5 steps from 3,5-dibromo-2-hydroxypyridine with 50% overall yield.(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid) was used in this study.

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: (6-Chloro-5-methylpyridin-3-yl)boronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineOn September 16, 2020 ,《Multichromic Monolayer Terpyridine-Based Electrochromic Materials》 was published in ACS Applied Materials & Interfaces. The article was written by Laschuk, Nadia O.; Ahmad, Rana; Ebralidze, Iraklii I.; Poisson, Jade; Easton, E. Bradley; Zenkina, Olena V.. The article contains the following contents:

The article describes novel electrochromic materials (ECMs) that are based on a monolayer consisting of two or three isostructural metal complexes of 4′-(pyridin-4-yl)-2,2′:6′,2′′-terpyridine simultaneously deposited on surface-enhanced support. The support was made by screen printing of indium tin oxide (ITO) nanoparticles on ITO-glass and has a surface area sufficient for a monolayer to give color visible to the naked eye. The ability to sep. electrochem. address the oxidation state of the metal centers on the surface (i.e., Co2+/Co3+, Os2+/Os3+, and Fe2+/Fe3+) provides an opportunity to achieve several distinct color-to-color transitions, thus opening the door for constructing monolayer-based multicolor ECMs. The results came from multiple reactions, including the reaction of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine)

4′-(4-Pyridyl)-2,2′:6′,2”-terpyridine(cas: 112881-51-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Reference of 4′-(4-Pyridyl)-2,2′:6′,2”-terpyridineThe lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zinc Photocages with Improved Photophysical Properties and Cell Permeability Imparted by Ternary Complex Formation》 was written by Basa, Prem N.; Barr, Chelsea A.; Oakley, Kady M.; Liang, Xiaomeng; Burdette, Shawn C.. Application of 1539-42-0This research focused onzinc photocage photophys cell permeability ternary complex; crystal structure. The article conveys some information:

Photocaged complexes can control the availability of metal ions to interrogate cellular signaling pathways. The authors describe a new photocage, {bis[(2-pyridyl)methyl]amino}(9-oxo-2-xanthenyl)acetic acid (XDPAdeCage, 1), which utilizes a 2-xanthone acetic acid group to mediate a photodecarboxylation reaction. XDPAdeCage photolyzes with a quantum yield of 27%, and binds Zn2+ with 4.6 pM affinity, which decreases by over 4 orders of magnitude after photolysis. For comparison to the previous approach to Zn2+ release via photodecarboxylation, the analogous photocage {bis[(2-pyridyl)methyl]amino}(m-nitrophenyl)acetic acid (DPAdeCage, 2), which uses a m-nitrobenzyl chromophore, was also prepared and characterized. The advantages of the 2-xanthone acetic acid chromophore include red-shifted excitation and a higher extinction coefficient at the preferred uncaging wavelength. The neutral ternary complex of [Zn(XDPAdeCage)]+ with the anionic ligand pyrithione is membrane permeable, which circumvents the need to utilize invasive techniques to introduce intracellular Zn2+ fluctuations. Using fluorescent imaging, the authors have confirmed transport of Zn2+ across membranes; in addition, RT-PCR experiments demonstrate changes in expression of Zn2+-responsive proteins after photolysis. The experimental process involved the reaction of Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application of 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Application of 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, pharmacophores, and mechanism study of pyridin-2(1H)-one derivatives as regulators of translation initiation factor 3a》 was published in Archiv der Pharmazie (Weinheim, Germany) in 2013. These research results belong to Zhu, Weixing; Shen, Jie; Li, Qianbin; Pei, Qi; Chen, Jun; Chen, Zhuo; Liu, Zhaoqian; Hu, Gaoyun. Computed Properties of C13H11NO3 The article mentions the following:

Twenty-seven 1,5-disubstituted-pyridin-2(1H)-one derivatives were synthesized and evaluated for their anticancer and antifibrosis activity by A549 and NIH3T3 cell viability assays, resp. To study the selectivity between the cancer and fibrosis cell lines, pharmacophore models (F1-F4) were built in advance for compounds with pyridin-2(1H)-one scaffold, which revealed the relationship between the occupation of the aromatic sub-site F4 and potent anti-cancer activity. The relationship between structure and anti-cancer activity for all target compounds is also reported herein: 1-Phenyl-5-((m-tolylamino)methyl)pyridine-2(1H)-one (22) displayed both potency and selectivity (IC50 = 0.13 mM) toward the A549 cell line through the inhibition of translation initiation, especially by eIF3a suppression, and can be treated as a lead for the design of novel eIF3a regulators and anti-lung cancer agents. In the part of experimental materials, we found many familiar compounds, such as Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3Computed Properties of C13H11NO3)

Methyl 6-oxo-1-phenyl-1,6-dihydropyridine-3-carboxylate(cas: 77837-09-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Computed Properties of C13H11NO3 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Radical Stabilization of a Tripyridinium-Triazine Molecule Enables Reversible Storage of Multiple Electrons》 was written by Huang, Jinghua; Hu, Shuzhi; Yuan, Xianzhi; Xiang, Zhipeng; Huang, Mingbao; Wan, Kai; Piao, Jinhua; Fu, Zhiyong; Liang, Zhenxing. Computed Properties of C6H4N2This research focused ontripyridinium triazine radical stabilization; aqueous; multi-electron storage; pyridinium; radical stabilization; triazine. The article conveys some information:

A novel organic mol., 2,4,6-tris[1-(trimethylamonium)propyl-4-pyridiniumyl]-1,3,5-triazine hexachloride, was developed as a reversible six-electron storage electrolyte for use in an aqueous redox flow battery (ARFB). Physicochem. characterization reveals that the mol. evolves from a radical to a biradical and finally to a quinoid structure upon accepting four electrons. Both the diffusion coefficient and the rate constant were sufficiently high to run a flow battery with low concentration and kinetics polarization losses. In a demonstration unit, the assembled flow battery affords a high specific capacity of 33.0 Ah L-1 and a peak power d. of 273 mW cm-2. This work highlights the rational design of electroactive organics that can manipulate multi-electron transfer in a reversible way, which will pave the way to development of energy-dense, manageable and low-cost ARFBs. After reading the article, we found that the author used 4-Cyanopyridine(cas: 100-48-1Computed Properties of C6H4N2)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Computed Properties of C6H4N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Merging C-H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis》 was written by Jiang, Xunjin; Zeng, Zhixiong; Hua, Yuhui; Xu, Beibei; Shen, Yang; Xiong, Jing; Qiu, Huijuan; Wu, Yifan; Hu, Tianhui; Zhang, Yandong. Electric Literature of C6H6BrNThis research focused onvinyl arylpyridine regioselective vinylation photochem aza electrocyclization anticancer DFT; dihydropyridoisoquinolinium preparation; dihydrobenzoquinoline preparation. The article conveys some information:

Pyridinium-containing polyheterocycles exhibit distinctive biol. properties and interesting electrochem. and optical properties and thus are widely used as drugs, functional materials, and photocatalysts. Here, we describe a unified two-step strategy by merging Rh-catalyzed C-H vinylation with two switchable electrocyclizations, including aza-6π-electrocyclization and all-carbon-6π-electrocyclization, for rapid and divergent access to dihydropyridoisoquinoliniums and dihydrobenzoquinolines. Through computation, the high selectivity of aza-electrocyclization in the presence of an appropriate “”HCl”” source under either thermal conditions or photochem. conditions is shown to result from the favorable kinetics and symmetries of frontier orbitals. We further demonstrated the value of this protocol by the synthesis of several complex pyridinium-containing polyheterocycles, including the two alkaloids berberine and chelerythrine. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Influence of Zinc on the Acute Changes in Erythropoietin and Proinflammatory Cytokines with Hypoxia》 was written by Baranauskas, Marissa N.; Powell, Joseph; Fly, Alyce D.; Martin, Bruce J.; Mickleborough, Timothy D.; Paris, Hunter L.; Chapman, Robert F.. Formula: C6H5NO2This research focused onzinc erythropoietin proinflammatory cytokine hypoxia; acclimatization; altitude training; antioxidants; interleukin-6; nutritional strategies. The article conveys some information:

Baranauskas, Marissa N., Joseph Powell, Alyce D. Fly, Bruce J. Martin, Timothy D. Mickleborough, Hunter L. Paris, and Robert F. Chapman. Influence of zinc on the acute changes in erythropoietin and proinflammatory cytokines with hypoxia. High Alt Med Biol. 22: 148-156, 2021. Considerable, unexplained, interindividual variability characterizes the erythropoietin (EPO) response to hypoxia, which can impact hematol. acclimatization for individuals sojourning to altitude. Zinc supplementation has the potential to alter EPO by attenuating increases in inflammation and oxidative stress. Yet, the application of such an intervention has not been evaluated in humans. In this proof-of-concept study, we aimed to evaluate the EPO and inflammatory responses to acute hypoxia in human participants following chronic zinc supplementation. Nine phys. active participants (men n = 5, women n = 4, age 28 ± 4 years, height 176 ± 11 cm, mass 77 ± 21 kg) were exposed to 12 h of normobaric hypoxia simulating an altitude of 3,000 m (FiO2 = 0.14) before and after 8 wk of supplementation with 40 mg/day of elemental zinc from picolinate. Blood samples for subsequent anal. of serum zinc, EPO, superoxide dismutase (extracellular superoxide dismutase [EC-SOD]), C-reactive protein (CRP), and proinflammatory cytokines were obtained pre- and postsupplementation and exposure to hypoxia. After zinc supplementation, EPO increased by 64.9 ± 36.0% (mean ± standard deviation) following 12 h of hypoxia, but this response was not different from presupplementation (70.8 ± 46.1%). Considerable interindividual (range: -1% to +208%) variability was apparent in the acute EPO response. While most markers of inflammation did not change with hypoxia, interleukin-6 concentrations increased from 1.17 ± 0.05 to 1.97 ± 0.32 pg/mL during the final 6 h. The acute EPO response at 12 h was not related to changes in serum zinc, EC-SOD, CRP, or proinflammatory cytokines. Zinc supplementation does not influence the acute EPO or inflammatory response with short-term exposure to moderate levels of normobaric hypoxia (3,000 m) in apparently healthy young adults. In the experiment, the researchers used Picolinic acid(cas: 98-98-6Formula: C6H5NO2)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Identification of the first potent, selective and bioavailable PPARα antagonist》 was written by Bravo, Yalda; Baccei, Christopher S.; Broadhead, Alex; Bundey, Richard; Chen, Austin; Clark, Ryan; Correa, Lucia; Jacintho, Jason D.; Lorrain, Daniel S.; Messmer, Davorka; Stebbins, Karin; Prasit, Peppi; Stock, Nicholas. Application of 13534-97-9This research focused ontriazolone containing biaryl sulfonamide preparation SAR PPAR alpha antagonist; Antagonist; Cancer; Fatty acid oxidation; Nuclear hormone receptor; PPAR alpha. The article conveys some information:

The discovery and SAR of a novel series of potent and selective PPARα antagonists are herein described. Exploration of replacements for the labile acyl sulfonamide linker led to a biaryl sulfonamide series of which compound I proved to be suitable for further profiling in vivo. Compound I demonstrated excellent potency, selectivity against other nuclear hormone receptors, and good pharmacokinetics in mouse. In the experimental materials used by the author, we found 6-Bromopyridin-3-amine(cas: 13534-97-9Application of 13534-97-9)

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application of 13534-97-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem