Category: pyridine-derivatives

Guo, Xuan; Lv, Fang; Zhao, Zifeng; Gu, Jiannan; Qu, Bo; Xiao, Lixin; Chen, Zhijian published the artcile< Spirobifluorene-based oligopyridine derivatives as electron-transporting materials for green phosphorescent organic light-emitting diodes>, Synthetic Route of 329214-79-1, the main research area is spirobifluorene oligopyridine electron transporting material phosphorescent OLED.

The electron-transporting materials (ETMs), 2,7-bis(3,5-di (pyridin-3-yl)phenyl)-9,9′-spirobi [fluorene] (3-4PySF) and 2,7-bis(3,5-di (pyridin-4-yl)phenyl)-9,9′-spirobi [fluorene] (4-4PySF) were designed and synthesized by combining spirobifluorene moiety with di(pyridine-3-yl)phenyl and di(pyridine-4-yl)phenyl, resp. The spirobifluorene moiety improves materials’ rigid twisted structure to ensure the morphol. stability of amorphous film, and pyridine acts as electron acceptor to enhance electron-transporting ability of materials. The dependence of electron-transporting property on the position of substituted pyridine rings was studied. The m.p. (Tm) of 4-4PySF is estimated to be 41°C higher than that of 3-4PySF. And the higher c.d. in the electron only devices exhibited by 4-4PySF revealed the effect of nitrogen atom position on the charge-transporting properties. Green PhOLEDs based on bis(2-phenylpyridine)iridium (III) (2,2,6,6-tetramethylheptane-3,5-diketonate) (Ir (ppy)2tmd) as the emitter and 3-4PySF, 4-4PySF and 1,3,5-tris(N-phenylbenzimid azol-2-yl-benzene (TPBi) as ETMs were fabricated. Compared to the device based on the conventional ETM TPBi, the devices based on new ETMs exhibited a higher maximum external quantum efficiency (EQE) of 20.5% and a lower turn-on voltage (Von) of 2.6 V.

Organic Electronics published new progress about Crystal structure. 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Synthetic Route of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jalba, Angela; Levitre, Guillaume; Keipour, Hoda; Lauzon, Samuel; Ollevier, Thierry published the artcile< New chiral bis(oxazolinyl)bipyridine ligands and application in the iron catalyzed asymmetric hydrosilylation of ketones>, Electric Literature of 147409-41-4, the main research area is chiral bis oxazolinyl bipyridine ligand preparation catalyst; iron catalyzed asym hydrosilylation acetophenone ketone.

C2 sym. 6,6′-bis(oxazolinyl)-2,2′-bipyridine (bipybox) chiral ligands have been synthesized from readily available 2,2′-bipyridine. Catalytic asym. hydrosilylation of ketones was studied using this family of ligands in the presence of iron(II) acetate.

French-Ukrainian Journal of Chemistry published new progress about Chiral ligands Role: CAT (Catalyst Use), RCT (Reactant), SPN (Synthetic Preparation), USES (Uses), RACT (Reactant or Reagent), PREP (Preparation). 147409-41-4 belongs to class pyridine-derivatives, and the molecular formula is C22H26N4O2, Electric Literature of 147409-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Ruixin; Wang, Liang; Zhang, Kena; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng published the artcile< Facile synthesis of trifluoroethyl aryl ethers through copper-catalyzed coupling of CF3CH2OH with aryl- and heteroaryl boronic acids>, Related Products of 832735-54-3, the main research area is trifluoroethyl aryl ether preparation catalytic Chan Lam coupling reaction; trifluoroethanol coupling aryl boronic acid copper catalyst.

An efficient copper-catalyzed Chan-Lam reaction of trifluoroethanol with a variety of aryl- and heteroaryl boronic acids has been developed. This research provides a practical method to synthesize trifluoroethyl aryl ethers in moderate to good yields under mild conditions.

Tetrahedron Letters published new progress about Alkyl aryl ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, Related Products of 832735-54-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bennasar, M.-Lluiesa; Zulaica, Ester; Juan, Cecilia; Alonso, Yolanda; Bosch, Joan published the artcile< Addition of Ester Enolates to N-Alkyl-2-fluoropyridinium Salts: Total Synthesis of (±)-20-Deoxycamptothecin and (+)-Camptothecin>, Related Products of 131747-55-2, the main research area is ester enolate addition fluoropyridinium salt; deoxycamptothecin total synthesis; camptothecin total synthesis.

Several 4-substituted dihydropyridones or 2-pyridones have been prepared by nucleophilic addition of α-(methylsulfanyl)ester enolates to N-alkyl-2-fluoropyridinium salts, followed by acid hydrolysis or oxidation with concomitant hydrolysis, of the intermediate 2-fluoro-1,4-dihydropyridine adducts, resp. Addition of the enolate derived from iso-Pr α-(methylsulfanyl)butyrate to N-(quinolylmethyl)-2-fluoropyridinium triflate followed by DDQ treatment gave a pyridone I, from which (±)-20-deoxycamptothecin a known precursor of camptothecin was synthesized by a radical cyclization-desulfurization, with subsequent elaboration of the lactone E ring by chemoselective reduction A similar sequence starting from the enolate of a chiral 2-hydroxybutyric acid derivative (II) provides access to natural (+)-camptothecin.

Journal of Organic Chemistry published new progress about Addition reaction. 131747-55-2 belongs to class pyridine-derivatives, and the molecular formula is C6H6FNO, Related Products of 131747-55-2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cai, Hongyun; Datta Khanal, Hari; Rok Lee, Yong published the artcile< Iodine-Catalyzed Annulations of 2-Amino Carbonyls for Diverse 1-Azaxanthones, Quinolines, and Naphthyridines>, COA of Formula: C6H6N2O, the main research area is amino formylchromone enamine iodine catalyst tandem cycloaddition green chem; azaxanthone preparation; carbonyl aniline enamine iodine catalyst tandem cycloaddition green chem; quinoline preparation; aminonicotinaldehyde enamine iodine catalyst tandem cycloaddition green chem; naphthyridine preparation.

An efficient and facile iodine-catalyzed reaction of 2-amino carbonyls with β-enamino esters or β-enaminones afforded 1-azaxanthones, quinolines and naphthyridines in good to excellent yields. This novel catalytic [4+2] annulation reaction proceeded through a cascade I2-activation, Michael addition, intramol. aldol reaction and aromatization.

Asian Journal of Organic Chemistry published new progress about [4+2] Cycloaddition reaction. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, COA of Formula: C6H6N2O.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gu, Yiting; Shen, Yangyang; Zarate, Cayetana; Martin, Ruben published the artcile< A Mild and Direct Site-Selective sp2 C-H Silylation of (Poly)Azines>, Product Details of C6H4F3N, the main research area is silylation pyridine pyrimidine pyrazine quinoline silyl dioxaborolane reagent; base promoted silylation azine borylsilane regioselective orthogonal process.

A base-mediated protocol that allows for the site-selective sp2 C-H silylation of pyridines, pyrazines, pyridazines, pyrimidines and quinolines by Et3SiBpin is described. The substitution typically proceeds in 4- or 2-position of the pyridine ring. This method is distinguished by its mild conditions, simplicity and excellent site-selective modulation for a diverse set of azines, even in the context of late-stage functionalization, while exhibiting orthogonal reactivity with classical silylation reactions.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (borylsilanes). 3796-23-4 belongs to class pyridine-derivatives, and the molecular formula is C6H4F3N, Product Details of C6H4F3N.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Jian-Wei; Xiong, Yuan; Wang, Feng; Zhang, Fu-Mao; Yang, Xiaodi; Lin, Guo-Qiang; Tian, Ping; Ge, Guangbo; Gao, Dingding published the artcile< Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19>, Related Products of 396092-82-3, the main research area is dihydrophenanthrene derivative SARS CoV2 coronavirus 3CLpro inhibitor COVID19; 9,10-Dihydrophenanthrenes; COVID-19; SARS-CoV-2 3CL(pro); Structure-activity relationships.

The epidemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious therapeutics are urgently needed. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive drug target for fighting COVID-19. Herein, we report the discovery of 9,10-dihydrophenanthrene derivatives as non-peptidomimetic and non-covalent inhibitors of the SARS-CoV-2 3CLpro. The structure-activity relationships of 9,10-dihydrophenanthrenes as SARS-CoV-2 3CLpro inhibitors have carefully been investigated and discussed in this study. Among all tested 9,10-dihydrophenanthrene derivatives, C1 and C2 display the most potent SARS-CoV-2 3CLpro inhibition activity, with IC50 values of 1.55 ± 0.21μM and 1.81 ± 0.17μM, resp. Further enzyme kinetics assays show that these two compounds dose-dependently inhibit SARS-CoV-2 3CLprovia a mixed-inhibition manner. Mol. docking simulations reveal the binding modes of C1 in the dimer interface and substrate-binding pocket of the target. In addition, C1 shows outstanding metabolic stability in the gastrointestinal tract, human plasma, and human liver microsome, suggesting that this agent has the potential to be developed as an orally administered SARS-CoV-2 3CLpro inhibitor.

European Journal of Medicinal Chemistry published new progress about Anticoronaviral agents. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Related Products of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yongtao; Luo, Xiaohe; Guo, Qingxiang; Nie, Yongwei; Wang, Tianqi; Zhang, Chao; Huang, Zhi; Wang, Xin; Liu, Yanhua; Chen, Yanan; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong published the artcile< Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)-N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetylase 1 (HDAC1) against Malignant Cancer>, Product Details of C10H15N3O2, the main research area is pyrrolopyrimidine preparation CDK4 CDK9 HDAC1 inhibitor treatment malignant cancer.

A series of highly potent, selective inhibitors targeting both CDK4/9 and HDAC1 have been designed and synthesized. N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)phenyl)-N8-hydroxyoctanediamide (I) was discovered. The lead compound I with excellent CDK4/9 and HDAC1 inhibitory activity of IC50 = 8.8, 12, and 2.2 nM, resp., can effectively induce apoptosis of cancer cell lines. The kinase profiling of compound I showed excellent selectivity and specificity. Compound I induces G2/M arrest in high concentration and G0/G1 arrest in low concentration to prevent the proliferation and differentiation of cancer cells. Mice bared-breast cancer treated with I showed significant antitumor efficacy. The insight into mechanisms of I indicated that it could induce cancer cell death via cell apoptosis based on CDK4/9 and HDAC1 repression and phosphorylation of p53. The data demonstrated the compound I could be a promising drug candidate for cancer therapy.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 220731-04-4 belongs to class pyridine-derivatives, and the molecular formula is C10H15N3O2, Product Details of C10H15N3O2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jiang, Ze-Zhen; Gao, Ang; Li, Hao; Chen, Di; Ding, Chang-Hua; Xu, Bin; Hou, Xue-Long published the artcile< Enantioselective Synthesis of Chromenes via a Palladium-Catalyzed Asymmetric Redox-Relay Heck Reaction>, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole, the main research area is chromene enantioselective synthesis palladium catalyzed Heck redox relay; Heck reaction; asymmetric catalysis; boronic acids; chromenes; palladium.

A palladium-catalyzed asym. redox-relay Heck reaction of 4H-chromenes and arylboronic acids has been successfully developed. The reaction proceeded in moderate to good yields with good to high enantioselectivities. The resulting product is an advanced intermediate of bio-active compound BW683C.

Chemistry – An Asian Journal published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Recommanded Product: (S)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem