Category: pyridine-derivatives

Catarineu, Noelle R.; Schoedel, Alexander; Urban, Philipp; Morla, Maureen B.; Trickett, Christopher A.; Yaghi, Omar M. published the artcile< Two Principles of Reticular Chemistry Uncovered in a Metal-Organic Framework of Heterotritopic Linkers and Infinite Secondary Building Units>, COA of Formula: C18H22BNO3, the main research area is zinc MOF heterotritopic benzoate benzosemiquinonate oxidopyridine linker solvothermal preparation; crystal structure zinc MOF heterotritopic benzoate benzosemiquinonate oxidopyridine linker; helicity zinc MOF heterotritopic benzoate benzosemiquinonate oxidopyridine linker.

Structural diversity of metal-organic frameworks (MOFs) was largely limited to linkers with at most two different types of coordinating groups. MOFs constructed from linkers with three or more nonidentical coordinating groups were not explored. Here, the authors report a robust and porous crystalline MOF, Zn3(PBSP)2 or MOF-910, constructed from a novel linker PBSP (phenylyne-1-benzoate, 3-benzosemiquinonate, 5-oxidopyridine) bearing three distinct types of coordinative functionality. The MOF adopts a complex and previously unreported topol. termed tto. The authors’ study suggests that simple, sym. linkers are not a necessity for formation of crystalline extended structures and that new, more complex topologies are attainable with irregular, heterotopic linkers. This work illustrates two principles of reticular chem.: first, selectivity for helical over straight rod secondary building units (SBUs) is achievable with polyheterotopic linkers, and second, the pitch of the resulting helical SBUs may be fine-tuned based on the metrics of the polyheterotopic linker.

Journal of the American Chemical Society published new progress about Crystal structure. 832735-54-3 belongs to class pyridine-derivatives, and the molecular formula is C18H22BNO3, COA of Formula: C18H22BNO3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Avci, Davut; Alturk, Sumeyye; Sonmez, Fatih; Tamer, Omer; Basoglu, Adil; Atalay, Yusuf; Zengin Kurt, Belma; Dege, Necmi published the artcile< A novel series of mixed-ligand M(II) complexes containing 2,2′-bipyridyl as potent α-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and molecular docking>, Application of C10H8N2, the main research area is 2,2′-Bipyridyl and 6-methylpyridine-2-carboxylic acid; DFT/HSE06; Docking; XRD, FT-IR and UV–Vis; α-Glucosidase.

Diabetes mellitus (DM) is a common degenerative disease and characterized by high blood glucose levels. Since the effective antidiabetic treatments attempt to decrease blood glucose levels, keeping glucose under control is very important. Recent studies have demonstrated that α-glucosidase inhibitor improves postprandial hyperglycemia and then reduces the risk of developing type 2 diabetes in patients. Therefore, the design and synthesis of high affinity glucosidase inhibitors are of great importance. In this regard, novel series of mixed-ligand M(II) complexes containing 2,2′-bipyridyl {[Hg(6-mpa)2(bpy)(OAc)]·2H2O, (1), [Co(6-mpa)2(bpy)2], (2), [Cu(6-mpa)(bpy)(NO3)]·3H2O, (3), [Mn(6-mpa)(bpy)(H2O)2], (4), [Ni(6-mpa)(bpy)(H2O)2]·H2O, (5), [Fe(6-mpa)(bpy)(H2O)2]·2H2O, (6), [Fe(3-mpa)(bpy)(H2O)2]·H2O, (7)} were synthesized as potential α-glucosidase inhibitors. Their effects on α-glucosidase activity were evaluated. All synthesized complexes displayed α-glucosidase inhibitory activity with IC50 values ranging from 0.184 ± 0.015 to > 600 μM. The exptl. spectral analyses were carried out using FT-IR and UV-Vis spectroscopic techniques for these complexes characterized by XRD and LC-MS/MS. Moreover, the calculations at d. functional theory approximation were used to obtain optimal mol. geometries, vibrational wavenumbers, electronic spectral behaviors, and major contributions to the electronic transitions for the complexes 1-7. Finally, to display interactions between the synthesized complexes and target protein (the template structure Saccharomyces cerevisiae isomaltase), the mol. docking study was carried out.

JBIC, Journal of Biological Inorganic Chemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Application of C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xu, Hai-Feng; Pan, You-Lu; Li, Gang-Jian; Hu, Xu-Yang; Chen, Jian-Zhong published the artcile< Copper(II)-Catalyzed Direct C-H (Hetero)arylation at the C3 Position of Indoles Assisted by a Removable N,N-Bidentate Auxiliary Moiety>, Electric Literature of 329214-79-1, the main research area is arylated indole regioselective preparation; indole arylboronic ester arylation copper catalyst.

The regioselective arylation of inert C3-H bonds in indoles reacting with arylboronates via effective copper-mediated catalysis with the aid of a facile and removable 2-pyridinylisopropyl (PIP) group without ligand participation was reported. This newly established method features high compatibility with diverse functional groups between coupling partners, including both indole substrates and arylboron reagents, consequentially leading to operational simplicity and providing access to generate the desired arylated products I [R = H, 4-Me, 5-MeO, 6-Br, etc.; R1 = Me, Bn; Ar = Ph, 2-thienyl, 3-pyridyl, etc.] in good to excellent yields of up to 97%. Synthetically, the PIP-derived amide moiety could subsequently be readily removed under mild reaction conditions to produce useful indolecarboxylic acids for further transformation.

Journal of Organic Chemistry published new progress about Amides, secondary Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 329214-79-1 belongs to class pyridine-derivatives, and the molecular formula is C11H16BNO2, Electric Literature of 329214-79-1.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Salipante, Paul F.; Dharmaraj, Vishnu L.; Hudson, Steven D. published the artcile< Entrance effects and high shear rate rheology of shear-banding wormlike micelle fluids in a microcapillary flow>, Formula: C21H38ClN, the main research area is cetylpyridinium chloride sodium salicylate micelle fluid shear rate viscosity.

The viscosity of a shear-banding wormlike micelle solution at high shear rates is investigated by capillary rheol. and particle streak velocimetry. Measurements of the flow profile and pressure gradient show an extended entrance region, which exceeds a length to diameter ratio of 100, to reach a fully developed flow. We characterized this entrance region for capillaries with different cross sections and used the results to select a downstream portion of the capillary, where viscosity measurements can be made on fully developed flow. Measurements from this portion of the channel show a shear-thinning power-law behavior for all channel geometries from shear rates of 1000-120000s-1. Varying the surfactant concentration shows two distinct power-law behaviors that depend on both the shear rate and the concentration and are an indication of change in the micelle length. (c) 2020 American Institute of Physics.

Journal of Rheology (Melville, NY, United States) published new progress about Elasticity. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Formula: C21H38ClN.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ebrahimi, Ali; Schwartzman, Julia; Cordero, Otto X. published the artcile< Multicellular behaviour enables cooperation in microbial cell aggregates>, Name: 1-Hexadecylpyridin-1-ium chloride, the main research area is Vibrio multicellular behavior cell aggregation; alginate; microbial aggregate; self-organization; trait-based model.

Oligosaccharides produced from the extracellular hydrolysis of biol. materials can act as common goods that promote cooperative growth in microbial populations, whereby cell-cell aggregation increases both the per capita availability of resources and the per-cell growth rate. We built a computational model, which predicts cooperation is restricted in dense cell aggregates larger than 10μm because of the emergence of polymer and oligomer counter gradients. We compared these predictions to experiments performed with two well-studied alginate-degrading strains of Vibrio splendidus, which varied in their ability to secrete alginate lyase. We observed that both strains can form large aggregates (less than 50μm), overcoming diffusion limitation by rearranging their internal structure. The stronger enzyme producer grew non-cooperatively and formed aggregates with internal channels that allowed exchange between the bulk environment and the aggregate, whereas the weak enzyme producer showed strongly cooperative growth and formed dense aggregates in which cells near the core mixed by active swimming. Our simulations suggest that the mixing and channelling reduce diffusion limitation and allow cells to uniformly grow in aggregates. Together, these data demonstrate that bacterial behavior can help overcome competition imposed by resource gradients within cell aggregates. This article is part of a discussion meeting issue ‘Single cell ecol.’.

Philosophical Transactions of the Royal Society, B: Biological Sciences published new progress about Cell aggregation. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Name: 1-Hexadecylpyridin-1-ium chloride.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaur, Gurpreet; Garg, Preeti; Kaur, Baljinder; Chaudhary, Ganga Ram; Kumar, Sandeep; Dilbaghi, Neeraj; Hassan, P. A.; Aswal, V. K. published the artcile< Synthesis, thermal and surface activity of cationic single chain metal hybrid surfactants and their interaction with microbes and proteins>, Related Products of 123-03-5, the main research area is microbe protein metal hybrid surfactant cationic chain surface activity.

A series of water-soluble metal functionalized surfactants have been prepared using com. available surfactant cetyl pyridinium chloride and transition metal salts. These complexes were characterized in the solid state by elemental anal., FTIR, 1H NMR and thermogravimetric anal. The interfacial surface activity and aggregation behavior of the metallosurfactants were analyzed through conductivity, surface tension and small angle neutron scattering measurements. Our results show that the presence of metal ions as co-ions along with counter ions favors micellization at a low critical micellization concentration (CMC). Small angle neutron scattering revealed that the metallomicelles are of a prolate ellipsoidal shape and exhibit strong counterion binding. This article further describes the interaction of the metallosurfactants with transport protein Bovine Serum Albumin (BSA) using different spectroscopic techniques. A spectroscopic study was used to study the binding, interaction and quenching mechanism of BSA with the metallosurfactants. Gel electrophoresis (SDS-PAGE) and CD (CD) investigated the structural and conformational changes produced in BSA due to the metallosurfactants. The results indicate that there is an alteration in the secondary structure of BSA due to the electrostatic interaction between pos. head groups and metal co-ions of the metallosurfactants and neg. charged amino acids of BSA. As the concentration increases, the α-helicity of BSA decreases and all the three studied metallosurfactants gave comparable results. Finally, the in vitro cytotoxicity and antimicrobial activity of the metallosurfactants were evaluated against erythrocytes and microorganisms, which showed prominent effects related to the presence of a metal ion in metallomicelles of the hybrid surfactants.

Soft Matter published new progress about Antimicrobial agents. 123-03-5 belongs to class pyridine-derivatives, and the molecular formula is C21H38ClN, Related Products of 123-03-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chai, Huifang; Zeng, Xiaoping; Teng, Minggang; Duan, Lian published the artcile< Synthesis of 2, 3-dichloro-5-iodopyridine>, Quality Control of 13472-84-9, the main research area is dichloro iodopyridine synthesis.

In the paper, we introduced a approach to synthesize the title compound, was realized and manufactured from 2, 3-dichloropyridine via four steps. Its structure was verified by MS and 1H NMR. This synthetic route has the advantages of convenient operation and mild reaction conditions. The total product yield was 51%. This program is suitable for industrial production

Guangdong Huagong published new progress about Chlorination. 13472-84-9 belongs to class pyridine-derivatives, and the molecular formula is C6H6ClNO, Quality Control of 13472-84-9.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bubnov, Michael P.; Teplova, Irina A.; Cherkasova, Anna V.; Baranov, Evgenii V.; Fukin, Georgy K.; Romanenko, Galina V.; Bogomyakov, Artem S.; Starikov, Andrey G.; Cherkasov, Vladimir K.; Abakumov, Gleb A. published the artcile< Metal-ligand ferromagnetic exchange interactions in heteroligand bis-o-semiquinonato nickel complexes with 2,2'-dipyridine and 1,10-phenanthroline>, COA of Formula: C10H8N2, the main research area is nickel semiquinonate complex preparation ferromagnetic exchange; optimized mol structure nickel semiquinonate complex; crystal structure nickel semiquinonate complex.

Novel bis-o-semiquinonato nickel complexes (2,2′-bpy)Ni(3,6-DBSQ)2 (1) and (1,10-phen)Ni(3,6-DBSQ)2 (2) was synthesized (2,2′-bpy is 2,2′-dipyridine; 1,10-phen is 1,10-phenanthroline; 3,6-DBSQ is anion-radical of 3,6-tert-butyl-o-benzoquinone). Single crystal x-ray diffraction study indicated distorted octahedral environment of nickel atom in both complexes. Variable temperature magnetic susceptibility measurement detected predomination of ferromagnetic exchange interactions between high spin nickel ion and anion-radicals of o-semiquinones. DFT calculations are in a good agreement with exptl. structural and magnetic results.

Polyhedron published new progress about Crystal structure. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Budweg, Svenja; Junge, Kathrin; Beller, Matthias published the artcile< Transfer-dehydrogenation of secondary alcohols catalyzed by manganese NNN-pincer complexes>, SDS of cas: 350-03-8, the main research area is manganese pincer complex preparation crystal structure; secondary alc manganese pincer complex catalyst transfer dehydrogenation; ketone preparation.

Novel catalytic systems based on pentacarbonylmanganese bromide and stable NNN-pincer ligands were presented for the transfer-dehydrogenation of secondary alcs. to gave the corresponding ketones in good to excellent isolated yields. Best results were obtained using di-picolylamine derivatives as ligands and acetone as an inexpensive hydrogen acceptor. Besides high activity for benzylic substrates, aliphatic alcs., as well as steroid derivatives, were readily oxidized in the presence of the optimal phosphorus-free catalyst.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, SDS of cas: 350-03-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem