Lanthanide-based peptide-directed Vis/NIR imaging and inhibition of LMP1 was written by Chau, Ho-Fai;Wu, Yue;Fok, Wan-Yiu;Thor, Waygen;Cho, William Chi-Shing;Ma, Ping’an;Lin, Jun;Mak, Nai-Ki;Bunzli, Jean-Claude G.;Jiang, Lijun;Long, Nicholas J.;Lung, Hong Lok;Wong, Ka-Leung. And the article was included in JACS Au in 2021.Synthetic Route of C6H6BrNO This article mentions the following:
A lanthanide-based peptide-directed bioprobe LnP19 (Ln = Eu or Yb) is designed as an impressive example of a small mol.-based dual-functional probe for the EBV oncoprotein LMP1. The peptide P19 (Pra-KAhx-K-LDLALK-FWLY-K-IVMSDKW-K-RrRK) is designed to selectively bind to LMP1 by mimicking its TM1 region during oligomerization in lipid rafts while signal transduction is significantly suppressed. Immunofluorescence imaging and Western blotting results reveal that P19 can effectively inactivate the oncogenic cellular pathway nuclear factor κB (NF-κB) and contribute to a selective cytotoxic effect on LMP1-pos. cells. By conjugation with cyclen-based europium(III) and ytterbium(III) complexes, EuP19 and YbP19 were constructed to offer visible and near-IR LMP1-targeted imaging and cancer monitoring. In addition to the ability to target and inhibit LMP1 and to selective inhibit LMP1-pos. cells, the selective growth inhibition toward LMP1-pos. tumor by LnP19 is also demonstrated. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Synthetic Route of C6H6BrNO).
(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C6H6BrNO