Pyridine is colorless, but older or impure samples can appear yellow. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Electric Literature of 16133-25-8.
Chen, Hao;Chen, Xiuhui;Sun, Ping;Wu, Dan;Yue, Hu;Pan, Jintao;Li, Xinxuan;Zhang, Cheng;Wu, Xinyi;Hua, Lei;Hu, Wenhui;Yang, Zhongjin research published 《 Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity》, the research content is summarized as follows. A series of novel 5-amide benzofuran derivatives I [ R = ethylsulfonyl, benzoyl, methoxysulfamoyl, cyclohexylcarbamoyl, etc.] were designed and synthesized as NLRP3-inflammasome inhibitors. Compound I [ R = 2-methylpropanoyl] showed slightly increased activity (IC50 = 3.85μM) against IL-1β release. Notably, treatment with I [ R = 2-methylpropanoyl] was significantly inhibited NLRP3-mediated IL-1β release and ameliorate peritoneal inflammation in a mouse model of sepsis. Collectively, I [ R = 2-methylpropanoyl] was a promising lead compound for further chem. development as a NLRP3 inhibitor with anti-inflammation effects.
16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Electric Literature of 16133-25-8