Kinetics of reaction of pyridine 1-oxides with phosgene in methylene chloride was written by Chimishkyan, A. L.;Grabarnik, M. S.;Orlov, S. I.;Bodrov, D. E.. And the article was included in Zhurnal Organicheskoi Khimii in 1989.Quality Control of 3,5-Dimethylpyridine 1-oxide This article mentions the following:
Rate constants (k) were determined for the reactions of pyridine oxides I (R = 4-MeO, 4-Me, 3-Me, 2-Me, H, 3-Cl) and 2,3-, 3,5-, and 2,6-dimethylpyridine oxide with COCl2 to give 1,1′-(carbonyldioxy)bis[pyridinium] dichlorides. Linear relations between log k and substituent constants of R and dipole moments of I were obtained. The inductive and resonance effects of electron-donating R substituents make significant and comparable contributions to stabilizing the transition state. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Quality Control of 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 3,5-Dimethylpyridine 1-oxide