Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors was written by Cox, Jason M.;Harper, Bart;Mastracchio, Anthony;Leiting, Barbara;Roy, Ranabir Sinha;Patel, Reshma A.;Wu, Joseph K.;Lyons, Kathryn A.;He, Huaibing;Xu, Shiyao;Zhu, Bing;Thornberry, Nancy A.;Weber, Ann E.;Edmondson, Scott D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Name: 2-Bromo-3-(trifluoromethyl)pyridine This article mentions the following:
Substituted 3-aminopiperidines were evaluated as DPP-4 inhibitors. The inhibitors showed good DPP-4 potency with superb selectivity over other peptidases (QPP, DPP8, and DPP9). Selected DPP-4 inhibitors were further evaluated for their hERG potassium channel, calcium channel, Cyp2D6, and pharmacokinetic profiles. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Name: 2-Bromo-3-(trifluoromethyl)pyridine).
2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 2-Bromo-3-(trifluoromethyl)pyridine