Synthesis and antibacterial activity of novel fluoroquinolones containing substituted piperidines was written by Dang, Zhao;Yang, Yushe;Ji, Ruyun;Zhang, Shuhua. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Application In Synthesis of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:
The design and synthesis of new fluoroquinolone antibacterial agents, e.g., I, having substituted piperidine rings at the C-7 position are described. Most of the new compounds demonstrated high in vitro antibacterial activity. Several of them exhibited significant activities against Gram-pos. organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Application In Synthesis of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate