Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase was written by De Schutter, Joris W.;Zaretsky, Serge;Welbourn, Sarah;Pause, Arnim;Tsantrizos, Youla S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Recommanded Product: 131747-45-0 This article mentions the following:
A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate sub-pockets of the enzyme are presented. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Recommanded Product: 131747-45-0).
(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 131747-45-0