Derivatives of pyridine and quinoline. LXXXVII. Bromo derivatives of 3-hydroxypyridine was written by den Hertog, H. J.;Schepman, F. R.;de Bruyn, J.;Thysse, G. J. E.. And the article was included in Recueil des Travaux Chimiques des Pays-Bas in 1950.Safety of 2,6-Dibromo-3-hydroxypyridine This article mentions the following:
The preparation of 8 Br derivatives of 3-hydroxypyridine is described: 2-Br, m. 186.5-7°, from 2-nitro-3-ethoxypyridine as given previously (C.A. 43, 6625h) with HBr in HOAc; 4-Br, m. 123.5-4° (20% from 0.5 g. 3,4-dihydroxypyridine and 4 g. POBr3 at 130° for 4 hrs.; 5-Br, m. 166.5-7.5°, from 1.4 g. 5-bromo-3 ethoxypyridine heated 4 hrs. at 160-70° in 25 ml. aqueous 25% HCl; 6-Br, m. 135.5-6.5° (90-100% from 0.16 g. 6-bromo-3-ethoxypyridine heated in 40% of HBr 8 hrs. at 160°); 2,6-di-Br, m. 162-3°, from 0.5 g. 2-bromo-3-ethoxy-6-nitropyridine heated to 130° for 4 hrs. with 5 ml. of 40% HBr; 4,6(possibly 2,4)-di-Br, m. 190-1°, from 1 g. 2,4,6-tribromo-3-hydroxypyridine boiled 4-5 hrs. with 1.5 g. N2H4.H2O in 8 ml. EtOH; 2,4,6-tri-Br (I), m. 90.5-91° (50% by brominating 0.5 g. 3-hydroxypyridine in aqueous Br to discoloration). A similar product is obtained by brominating either 2-bromo-3-hydroxypyridine (45% yield, m. 86-7°) or 6-bromo-3-hydroxypyridine (65-70% yield, m. 85-8°). I (1 g.) treated with 0.8 g. NaOH in 18 ml. MeOH at 140° for 5 hrs. gives 2-methoxy-4,6-dibromo-3-hydroxypyridine, m. 86-7°. Hydrogenation in an alk. EtOH solution yields 2,3-dihydroxypyridine, m. 247-8°. Addition of N2H4.H2O in EtOH to I yields the hydrazinium salt of 2,4-6-tribromo-3-hydroxypyridine, C5H2ONBr3.N2H2, m. 179-9.5°. 2,4,5,6-Tetrabromo-3 hydroxypyridine, m. 146.5-7.5°, was prepared by adding 5-bromo-3-hydroxypyridine to aqueous HBr. solution In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Safety of 2,6-Dibromo-3-hydroxypyridine).
2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Safety of 2,6-Dibromo-3-hydroxypyridine