Palladium-Catalyzed Oxygenation of Unactivated sp3 C-H Bonds was written by Desai, Lopa V.;Hull, Kami L.;Sanford, Melanie S.. And the article was included in Journal of the American Chemical Society in 2004.Computed Properties of C8H11N This article mentions the following:
A new Pd-catalyzed method for the oxygenation of unactivated sp3 C-H bonds is described. A wide variety of alkane substrates containing readily available oxime and/or pyridine directing groups are oxidized with extremely high levels of chemo-, regio-, and in some cases diastereoselectivity. Thus, treatment of pinacolone O-Me oxime, Me3CC(:NOMe)Me, with 4.5 equiv PhI(OAc)2 in AcOH/Ac2O containing Pd(OAc)2 at 100° for 3.5 h gave 62% MeON:CMeC(CH2OAc)3. The substrate scope of these reactions is discussed, and the high selectivities are rationalized on the basis of the requirements of putative palladium alkyl intermediates. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Computed Properties of C8H11N).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C8H11N