Recyclable ionic liquid iodinating reagent for solvent-free, regioselective iodination of activated aromatic and heteroaromatic amines was written by Deshmukh, Amarsinh;Gore, Babasaheb;Thulasiram, Hirekodathakallu V.;Swamy, Vincent P.. And the article was included in RSC Advances in 2015.Synthetic Route of C10H16ClN This article mentions the following:
A simple, efficient method for iodination of activated aromatic amines [C6H5NH2, 2-BrC6H4NH2, 2,6-(H3C)2C6H3NH2, etc.] and heteroaromatic amines such as 1-methylimidazole, 8-hydroxyquinoline, 5-chloro-8-hydroxyquinoline using recyclable 1-butyl-3-methylpyridinium dichloroiodate (BMPDCl) as an ionic liquid iodinating reagent, in the absence of any solvent has been described. The main advantages are a simple efficient procedure, good yields and no need for any base/toxic heavy metals, or oxidizing agents. The ionic liquid was recovered and recycled in five subsequent reactions, without much loss of activity. This method was applied for the synthesis of the antiprotozoal drug iodoquinol and the antifungal drug clioquinol. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Synthetic Route of C10H16ClN).
1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C10H16ClN