Directed Palladium Catalyzed C-H (Ethoxycarbonyl)difluoromethylthiolation Reactions was written by Doche, Floriane;Escudero, Julien;Petit-Cancelier, Fabien;Xiong, Heng-Ying;Couve-Bonnaire, Samuel;Audisio, Davide;Poisson, Thomas;Besset, Tatiana. And the article was included in Chemistry – A European Journal.Name: 2-(m-Tolyl)pyridine This article mentions the following:
The unprecedented Pd-catalyzed (ethoxycarbonyl)difluoromethylthiolation reaction of various unsaturated derivatives was studied. In the presence of the (ethoxycarbonyl)difluoromethylsulfenamide reagent and under mild reaction conditions (60°C), both 2-(hetero)aryl and 2-(α-aryl-vinyl)pyridine derivatives e.g., I/II [R1 = Ph, 4-methylphenyl, 3-chlorophenyl, etc.; R2 = H, Ph; R1R2 = -(CH2)4-] were smoothly functionalized with this methodol. (37 examples, up to 87% yield). Moreover, the synthetic interest of this fluorinated moiety was further showcased by its conversion into various original fluorinated residues. Finally, a plausible mechanism for this transformation was suggested. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Name: 2-(m-Tolyl)pyridine).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Name: 2-(m-Tolyl)pyridine