Eremina, J. A.; Lider, E. V.; Kuratieva, N. V.; Samsonenko, D. G.; Klyushova, L. S.; Sheven’, D. G.; Trifonov, R. E.; Ostrovskii, V. A. published their research in Inorganica Chimica Acta in 2021. The article was titled 《Synthesis and crystal structures of cytotoxic mixed-ligand copper(II) complexes with alkyl tetrazole and polypyridine derivatives》.Category: pyridine-derivatives The article contains the following contents:
A series of mixed-ligand copper(II) complexes {[Cu(phen)(L1)2]·H2O}n (1), [Cu(dmphen)(L1)2] (2), [Cu(bipy)(L1)2] (3) and [Cu2(dmbipy)2(L1)4] (4), where HL1 – 5-methyltetrazole, bipy – 2,2′-bipyridine, dmbipy – 4,4′-dimethyl-2,2′-bipyridine, phen – 1,10-phenanthroline, dmphen – 4,7-dimethyl-1,10-phenanthroline, has been synthesized. The complexes have been characterized by elemental anal., IR spectroscopy and powder x-ray diffraction. Crystal structures of some complexes have been determined by single-crystal x-ray diffraction anal. and showed distorted tetragonal-pyramidal (1) and square pyramidal ([Cu2(bipy)2(L1)4]·DMSO and 4) geometries. The crystal structure of {(H3O)0.5[Cu(phen)(μ3-H2L2)0.5(μ3-HL2)0.5]·H2O}n (5) with alkyl tetrazole H4L2 (1,3,3,5-tetra-(1H-tetrazol-5-yl)-pentane) has also been determined The complexes 1 and 5 have a zig-zag polymeric structure in which each copper(II) ion is coordinated by five N atoms, belonging to three different tetrazolate rings and one 1,10-phenantroline ligand, while [Cu2(bipy)2(L1)4]·DMSO and 4 are binuclear complexes. The effect of the compounds on viability of MCF-7 and Hep-2 cell lines has been investigated. Complexes 1, 2, 4 possess significant dose-dependent cytotoxic effect and 1, 2 are the most cytotoxic. In addition, stability of copper(II) complexes 1-4 in water-ethanol solution and phosphate buffer saline has been investigated by UV-vis spectroscopy. The interaction of complexes 1 and 3 with calf thymus DNA (CT-DNA) has also been studied by UV-vis spectroscopy. The results came from multiple reactions, including the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Category: pyridine-derivatives)
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Category: pyridine-derivatives Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.