Reference of 801303-22-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 801303-22-0, name is 2-Amino-5-fluoronicotinonitrile. A new synthetic method of this compound is introduced below.
To a solution of furan (16.6 mmol) in 50 mL THF at -78 C was slowly added 17 mmol n-BuLi (6.8 mL of a 2.5 M solution in hexanes). The solution was transferred to an ice water bath, and allowed to stir for 1.5 hours. The furanyllitium solution was returned to the -78 C bath prior to the addition of 2-amino-5-fluoronicotinonitrile (570 mg, 4.16 mmol) dissolved in 15 mL THF. The combined mixture was then returned to the 0 C ice water bath. After 30 minutes at 0 C the reaction was quenched with NH4CI (aq) and the organic layer washed several times with water, dried (MgS04), and concentrated under vacuum to yield 800 mg product, MS (M+H) = 206, H NMR (300 MHz, DMSO-D6) # ppm 6.69 (dd, J=3.39, 1.88 Hz, 1 H) 6.94 (d, J=3.39 Hz, 1 H) 7.30 (s, 2 H) 7.67 (dd, J=9.80, 3.01 Hz, 1 H) 7.96 (d, J=1.51 Hz, 1 H) 8.12 (d, J=3.01 Hz, 1 H) 10.85 (s, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,801303-22-0, 2-Amino-5-fluoronicotinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; ASTRAZENECA AB; WO2005/111001; (2005); A1;,
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