As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61830-40-8, name is 3,5-Dibromopicolinic acid, molecular formula is C6H3Br2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H3Br2NO2
To n-butyllithium (2.5 M in hexane, 12 mL, 30 mmol) in THF (40 mL) at -78 C was added a solution of 3,5-dibromopicolinic acid (4.0 g, 14 mmol) in THF (60 mL) over 30 minutes. The reaction was stirred at -78 C for 1 hour after which DMF (11 mL, 144 mmol) was added dropwise. The cold bath was allowed to expire while stirring for 12 h. Water was added followed by IN HC1 (30 mL). The pH was adjusted to pH 3-4 using IN NaOH. The solution was extracted with EtOAc while maintaining a pH of 3 to 4. The combined organic layerswere washed with water and brine, dried (MgS04), filtered, and concentrated in vacuo to provide the title compound Ab2 that was carried on directly.
With the rapid development of chemical substances, we look forward to future research findings about 61830-40-8.
Reference:
Patent; MERCK SHARP & DOHME CORP.; GILBERT, Eric, J.; CUMMING, Jared, N.; SCOTT, Jack, D.; WU, Wen-Lian; BURNETT, Duane, A.; STAMFORD, Andrew, W.; WO2014/150344; (2014); A1;,
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