Reference of 851179-01-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.851179-01-6, name is 3-Chloro-2,4-difluoropyridine, molecular formula is C5H2ClF2N, molecular weight is 149.5259, as common compound, the synthetic route is as follows.
A four-necked flask was charged with 2,4-difluoro-3-chloropyridine (29.9 g, 0.20 mol)Ethanol (240 mL),Hydrazine hydrate (80%, 25 g, 0.40 mol) was added dropwise with vigorous stirring,After heating and refluxing for 12 hours,The mixture was poured into 350mL water, analysisThe solid was filtered, washed with ethanol,Vacuum drying gave 18.7 g of 3-chloro-4-fluoro-2-hydrazinopyridine as yellowish solid in 58% yield.
Statistics shows that 851179-01-6 is playing an increasingly important role. we look forward to future research findings about 3-Chloro-2,4-difluoropyridine.
Reference:
Patent; Zhejiang Xin’an Chemical Group Co., Ltd.; Zhu Jianmin; Yu Shenluan; Li Qiaojun; Liu Chunjie; Fan Xiaotang; Jiang Zhe; Xu Yaqing; (19 pag.)CN104557860; (2017); B;,
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