Adding a certain compound to certain chemical reactions, such as: 874302-76-8, 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate, blongs to pyridine-derivatives compound. Quality Control of 4-nitrophenyl 2-(pyridin-2-yldisulfanyl)ethyl carbonate
To a solution of cabazitaxel (2.00 g, 2.40 mmol) and 2-(2- pyridinyldithio)ethanol p-nitrophenyl carbonate (915 mg, 2.60 mmol) in dichloromethane (48 mL) was added DMAP (439 mg, 3.60 mmol). The solution was stirred at room temperature overnight, then washed with 0.1N HCl (3 x 20 mL), brine (50 mL), and dried with sodium sulfate. The solvent was removed in vacuo, the the remaining residue purified by silica gel chromatography (2:1 petroleum ether:ethyl acetate) to give 4? (2.50 g, 2.38 mmol, 99% yield). LCMS m/z: 1049 (M + 1).
The synthetic route of 874302-76-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TARVEDA THERAPEUTICS, INC.; BILODEAU, Mark T.; SIMCOX, Mary; WHITE, Brian H.; KADIYALA, Sudhakar; WOOSTER, Richard; (178 pag.)WO2017/180834; (2017); A1;,
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