Application of 114080-94-3 ,Some common heterocyclic compound, 114080-94-3, molecular formula is C6H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Intermediate 27: IsoxazolordeltaLambda-cipyridin-S-yl-carbamic acid phenyl ester.; P-N oNryXNAoph W HTo a suspension of isoxazolo[5,4-c]pyridin-3-ylamine (1.49 g, 11.0 mmol) in CH3CN (50 ml_) was added phenyl chloroformate (0.696 ml_, 5.50 mmol). The reaction mixture was heated at 70 0C overnight, then cooled to rt, diluted with H2O (100 ml_) and saturated aqueous NaHCO3 (10 ml_). The resulting yellow precipitate was filtered and dried under vacuum to give isoxazolo[5,4-c]pyridin-3-yl-carbamic acid phenyl ester (1.099 g, 39%). MS (ESI+): calcd for Ci3H9N3O3 m/z 255.06, found 256.1 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,114080-94-3, its application will become more common.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BREITENBUCHER, J., Guy; KEITH, John, M.; TICHENOR, Mark, S.; CHAMBERS, Alison, L.; JONES, William, M.; HAWRYLUK, Natalie, A.; TIMMONS, Amy, K.; MERIT, Jeffrey, E.; SEIERSTAD, Mark, J.; WO2010/68453; (2010); A1;,
Pyridine – Wikipedia,
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