In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1254073-41-0, name is 5-Fluoropicolinohydrazide, the common compound, a new synthetic route is introduced below. Recommanded Product: 1254073-41-0
The title compound was prepared in an analogous method to that described in E1 11. To a solution of 4-[(2-chlorophenyl)carbonyl]-2-piperazinone (I4) (225 mg, 0.943 mmol) in Dichloromethane (5 ml) stirred under argon at room temp was added solid triethyloxonium tetrafluoroborate (179 mg, 0.943 mmol). The reaction mixture was stirred at RT for 2 hr. Solid 5-fluoro-2-pyridinecarbohydrazide (I24) (161 mg, 1.037 mmol) was added and the reaction mixture stirred at RT for 18 hr. The solvent was evaporated in vacuo, and the residue dissolved in n-butanol (5 ml) and stirred at 120 0C for 4 hr. The reaction mixture was cooled to room temperature and partitioned between Dichloromethane (~ 25 ml) and saturated brine (~ 25 ml). The aqueous phase was extracted wih Dichloromethane (2 x 25 ml) and the combined organic extracts washed with saturated brine (~ 25 ml), dried over sodium sulphate, and evaporated in vacuo to afford the crude product as a yellow oil. This was dissolved in 1 :1 MeOH:DMSO and purified by Open Access Mass Directed AutoPrep on Sunfire C18 column using Acetonitrile Water with a Formic acid modifier. The solvent was evaporated in vacuo and the residue dried overnight in a vacuum oven at 40 0C to give the required product as a white powder in 126.4 mg.LCMS: 2 minute run in MeCN. MH+ m/z = 358.03; RT = 0.80-0.82 min.
The synthetic route of 1254073-41-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
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