Extracurricular laboratory: Synthetic route of 2-Bromo-5-(ethylsulfonyl)pyridine

With the rapid development of chemical substances, we look forward to future research findings about 1227384-81-7.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1227384-81-7, name is 2-Bromo-5-(ethylsulfonyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H8BrNO2S

It can be manufactured by the method described in WO 2010/055004250 mg of 2-bromo-5- (ethanesulfonyl) pyridine,Bis (pinacolato) diboron 355 mg,[1,1′-bis (diphenylphosphino) ferrocene]Palladium (II) dichloride dichloromethaneAdduct 49 mg,A mixture of 294 mg of potassium acetate and 3 mL of dimethyl sulfoxide is stirred at 90 C. under a nitrogen atmosphere.After the reaction,The resulting mixture is filtered through Celite.The filtrate is concentrated under reduced pressure,2- (4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl) -5- (ethanesulfonyl) pyridine is obtained.

With the rapid development of chemical substances, we look forward to future research findings about 1227384-81-7.

Reference:
Patent; Sumitomo Chemical Chemicals company; Sasayama, Daisuke; Inui, Tomohiko; (102 pag.)JP2019/48845; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem