Extracurricular laboratory: Synthetic route of 3,5-Dichloropicolinamide

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5468-71-3, 3,5-Dichloropicolinamide.

Application of 5468-71-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5468-71-3, name is 3,5-Dichloropicolinamide. This compound has unique chemical properties. The synthetic route is as follows.

Example 1Preparation of 6-chloro-1-isopropyl-1H-imidazo[4,5-b]pyridin-2-ol; Example 1(a) 5-chloro-3-(isopropylamino)picolinamide: 3,5-Dichloropicolinamide (50 mg, 0.26 mmol, 1.0 equiv) and isopropylamine (225 uL, 2.6 mmol, 1.0 equiv) were combined in a microwave vial equipped with a stirbar, sealed and heated to 200 C. for 30 min. The mixture was then dissolved in dichloromethane and loaded onto a Biotage caplet. Purification by silica gel MPLC (13%-68% Et2O/Hexanes) provided the desired compound as a white solid (31 mg, 56%). m/z=214.1 [M+H]+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5468-71-3, 3,5-Dichloropicolinamide.

Reference:
Patent; Collibee, Scott; Lu, Pu-Ping; Ashcraft, Luke W.; Browne, William F.; Garard, Marc Andrew; Morgan, Bradley P.; Morgans, David J.; Bergnes, Gustave; Muci, Alex; US2008/242695; (2008); A1;,
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