As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41668-13-7, name is 5-Bromo-6-hydroxynicotinic acid, molecular formula is C6H4BrNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 5-Bromo-6-hydroxynicotinic acid
[0543] A solution of Example 117a (1 g, 4.58 mmol) and K2C03 (1.56 g, 13.76 mmol) in 10 mL of DMF, and was added Mel (0.7 mL, 11.46 mmol), the reaction was stirred at rt for 2.5 h. LCMS (BD01075-068) showed SM consumed, the mixture was poured into 30 mL water and stirred for 10 min. The mixture was extracted with EA (10 mL * 3). The combined organic phase was dried over MgS04, filtrated and the filtrate was concentrated under reduced pressure to get desired product (0.82 g, yield 73%) as yellow solid. LCMS [M+l] + = 246.0
With the rapid development of chemical substances, we look forward to future research findings about 41668-13-7.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (227 pag.)WO2018/151830; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem