One-step synthesis of pyrimido[1,2-a][1,8]naphthyridinones, pyrido[1,2-a]pyrimidinones and 1,8-naphthyridinones. Antihypertensive agents. V was written by Ferrarini, Pier Luigi;Mori, Claudio;Primofiore, Giampaolo;Calzolari, Lorella. And the article was included in Journal of Heterocyclic Chemistry in 1990.Quality Control of N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:
The cyclocondensation reaction of 2,6-diaminopyridine and 2-acetamido-6-aminopyridine with β-keto esters in polyphosphophoric acid to give 1,8-naphthyridinones, pyrido[1,2-a]pyrimidinones, and pyrimido[1,2-a][1,8]naphthyridinones was studied. Thus, cyclocondensation reaction of 2-acetamido-6-aminopyridine with ClCH2COCH2CO2Et in polyphosphoric acid at 80° for 4 h gave 42% pyrimidonaphthyridinone I, the structure of which was confirmed by x-ray anal. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Quality Control of N-(6-Aminopyridin-2-yl)acetamide).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Quality Control of N-(6-Aminopyridin-2-yl)acetamide