Scale-Up Synthesis of IID572: A New β-Lactamase Inhibitor was written by Furegati, Markus;Nocito, Sandro;Reck, Folkert;Casarez, Anthony;Simmons, Robert;Schuetz, Heiner;Koch, Guido. And the article was included in Organic Process Research & Development in 2020.Reference of 59718-84-2 This article mentions the following:
The new potentially best-in-class β-lactamase inhibitor IID572 (I) was discovered by a late stage functionalization approach. An alternative synthesis was developed to satisfy the short-term material need for toxicol. studies in animals. The new synthetic strategy was built on two key features, an intramol. azomethine ylide [3+2] cycloaddition that allowed the efficient formation of mol. complexity from readily available starting materials and an enzymic resolution that resulted in high optical purity of a key intermediate. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2Reference of 59718-84-2).
Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 59718-84-2