Regioselective C-H chlorination: towards the sequential difunctionalization of phenol derivatives and late-stage chlorination of bioactive compounds was written by Gao, Chao;Li, Hongchen;Liu, Miaochang;Ding, Jinchang;Huang, Xiaobo;Wu, Huayue;Gao, Wenxia;Wu, Ge. And the article was included in RSC Advances in 2017.COA of Formula: C11H9NO This article mentions the following:
A protocol for the auxillary directed C-H chlorination of phenol derivatives using catalytic amounts of palladium acetate that is amenable to the late-stage chlorination of diflufenican and estrone was developed. The 2-pyridine group allows for a highly efficient palladium-catalyzed chlorination and sequential ortho C-H functionalization reaction of phenol derivatives to produce a variety of sym. and unsym. 2,4,6-trisubstituted phenols. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0COA of Formula: C11H9NO).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·molâ? in pyridine vs. 150 kJ·molâ? in benzene). Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C11H9NO