Organocatalytic decarboxylative alkylation of N-hydroxy-phthalimide esters enabled by pyridine-boryl radicals was written by Gao, Liuzhou;Wang, Guoqiang;Cao, Jia;Yuan, Dandan;Xu, Cheng;Guo, Xuewen;Li, Shuhua. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Synthetic Route of C7H6ClNO2 This article mentions the following:
Synthesis of substituted tetrahydropyrans derivatives I [R1 = Me, Ph, 2-pyridyl, etc.; R2 = Me, CF3, 2-thienyl, etc.] and compounds, e.g., II via decarboxylative alkylation of N-hydroxyphthalimide (NHPI) based reactive esters with olefins using organocatalytic strategy was described. Control experiments and d. functional theory calculations suggested that these reactions involved a boryl-radical mediated decarboxylation pathway, which was different than the single electron transfer involved in decarboxylative alkylation reactions reported previously. This metal-free decarboxylative alkylation reaction features good functional compatibility, and broad substrate scope illustrated by the transformations of both the alkyl and aryl carboxylic acid derivatives In the experiment, the researchers used many compounds, for example, 2-(6-Chloropyridin-2-yl)acetic acid (cas: 885267-14-1Synthetic Route of C7H6ClNO2).
2-(6-Chloropyridin-2-yl)acetic acid (cas: 885267-14-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C7H6ClNO2