Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Related Products of 16133-25-8.
Ghosh, Animesh;Tan, Nigel C. S.;Shi, Raymond R. S.;Webster, Richard D.;Steele, Terry W. J. research published 《 Optimizing the Reduction Potential of Sulfonamides on Polyamidoamine Dendrimers》, the research content is summarized as follows. p-Toluenesulfonamide serves as an important functional group to protect alkyl amines. However, the electrochem. deprotection of sulfonamides requires relatively high reduction potentials (-2.4 V vs SCE) that would interfere with other functional groups. Previous investigations suggest that methods are available to decrease the reduction potential, but no systematic investigation has been conducted that evaluates the reduction potential as a function of aryl-substitution, mediator, or multi-arm grafting. Cyclic voltammetric studies of a library of bis-sulfonamides bearing different aryl substituents in DMF reveals that p-NO2 substituted bis-sulfonamide has the lowest reduction potential. Further investigations aimed at lowering the cathodic potential with polycyclic aromatic hydrocarbon mediators display negligible or no impact. This optimized condition was successfully applied to fully p-nitrobenzenesulfonyl protected generation-zero and generation-one polyamidoamine dendrimers (G0.0-PAMAM-Ns and G1.0-PAMAM-Ns, resp.), demonstrating successful amine protection and deprotection on dendrimers for the first time.
16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Related Products of 16133-25-8