Cobalt-Catalyzed C-H Acetoxylation of Phenols with Removable Monodentate Directing Groups: Access to Pyrocatechol Derivatives was written by Gou, Quan;Tan, Xiaoping;Zhang, Mingzhong;Ran, Man;Yuan, Tengrui;He, Shuhua;Zhou, Linzong;Cao, Tuanwu;Luo, Feihua. And the article was included in Organic Letters in 2020.Reference of 4783-68-0 This article mentions the following:
An efficient cobalt-catalyzed C-H acetoxylation of phenols ROR1 (R = Ph, 4-chlorophenyl, naphthalen-1-yl, quinolin-6-yl, etc.; R1 = pyridin-2-yl, 3-chloropyridin-2-yl, 3-methylpyridin-2-yl, pyrimidin-2-yl, 3-(2,4-difluorophenylaminocarbonyl)pyridin-2-yl) has been developed by using PIDA (phenyliodine diacetate) as a sole acetoxy source to synthesize pyrocatechol derivatives R2OR1 (R2 = 2-acetyloxyphenyl, 2-acetyloxy-4-chlorophenyl, 2-acetyloxynaphthalen-1-yl, 7-acetyloxyquinolin-6-yl, etc.) for the first time. The key feature of this method is the use of earth-abundant metal cobalt as the green and inexpensive catalyst for the acetoxylation of C(sp2)-H bonds under neutral reaction conditions. Furthermore, the gram-scale reaction and late-stage functionalization demonstrated the usefulness of this method. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Reference of 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of â?8.7 à 10â? cm3·molâ?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·molâ? in the liquid phase and 140.4 kJ·molâ? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one CâH in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Reference of 4783-68-0