Catalyst- and Solvent-Free Hydrophosphorylation of Ketones with Secondary Phosphine Oxides: Green Synthesis of Tertiary α-Hydroxyphosphine Oxides was written by Gusarova, Nina K.;Ivanova, Nina I.;Khrapova, Kseniya O.;Volkov, Pavel A.;Telezhkin, Anton A.;Larina, Lyudmila I.;Afonin, Andrei V.;Pavlov, Dmitry V.;Trofimov, Boris A.. And the article was included in Synthesis in 2020.Related Products of 91-02-1 This article mentions the following:
Tertiary α-hydroxyphosphine oxides were synthesized via the catalyst- and solvent-free reaction between available secondary phosphine oxides and aliphatic, aromatic and heteroaromatic ketones at 20-62° in near to 96-98% yield. The developed method meets the requirements of green chem. and the PASE (pot, atom, step economy) paradigm. According to quantum-chem. calculations at the B3LYP/6-311++G(d,p) level, the synthesized hydroxyphosphine oxides feature a weak (≈3 kcal·mol -1) O-H···O:P intramol. H bond. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Related Products of 91-02-1).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Related Products of 91-02-1