Mild C(sp3)-H Alkylation of 8-Methylquinolines with α,β-Unsaturated Carbonyl Compounds by Rhodium(III) Catalysis was written by Han, Shengnan;Ma, Wenbo;Zhang, Zhao;Liu, Lei;Tang, Mengyao;Li, Jie. And the article was included in Asian Journal of Organic Chemistry in 2017.Related Products of 644-98-4 This article mentions the following:
A straightforward approach to the synthesis of γ-quinolyl carbonyl compounds RCH2CH2CH2C(O)R1 (R = quinolin-8-yl, 6-chloroquinolin-8-yl, 7-methylquinolin-8-yl, etc.; R1 = Me, cyclohexyl, 1-naphthyl, furan-2-yl, benzo[d][1,3]dioxol-5-yl, etc.) has been developed by a rhodium(III)-catalyzed C(sp3)-H alkylation of 8-methylquinolines such as 8-methylquinoline, 5-chloro-8-methylquinoline, 5-styryl-8-methylquinoline, etc. with conjugated C=C multiple bonds. Remarkably, this C(sp3)-H functionalization proceeds under mild reaction conditions, obviates the need for external oxidants, and features high atom-economy, ample substrate scope and wide functional group tolerance. Mechanistic studies provided strong support for an irreversible C(sp3)-H bond activation. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Related Products of 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 644-98-4