Synthesis and biological screening of some new 2,5-disubstituted 1,3,4-oxadiazoles was written by Hemavathi, S. N.;Vishu Kumar, B. K.;Lokanatha Rai, K. M.. And the article was included in International Journal of Pharmacy and Pharmaceutical Sciences in 2011.Computed Properties of C12H8N4O This article mentions the following:
The emergence of bactericide resistance and fungicide resistance towards existing antimicrobial agents is one of the major motives for research and development of new mols. to defend them. Substituted 1,3,4-oxadiazoles are of considerable pharmaceutical and material interest, which is documented by a steadily increasing number of publications and patents. 1,3,4-Oxadiazoles show various biol. activities and have been synthesized from different compounds Research on 1,3,4-oxadiazole and their synthetic analogs have revealed a variety of pharmacol. activities including anti-microbial, anti-tubercular and insecticidal agents. Some of these compounds also display activity as analgesics, antiinflammatory agents, anticancer agents, anti-HIV agents, anti-Parkinson agents and anti-proliferate agents. The authors report novel derivatives of the title compounds and their evaluation as antibacterial agents and antifungal agents. Several 2,5-disubstituted 1,3,4-oxadiazole derivatives were prepared which contain pyridine or piperidine rings. The structure of synthesized compounds were confirmed by spectroscopic data, elemental anal. and the target compounds thus formed included 2-[5-(3-piperidinyl)-1,3,4-oxadiazol-2-yl]-1H-indole, 2-(3-piperidinyl)-5-(4-pyridinyl)-1,3,4-oxadiazole, 2-methoxy-4-[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]phenol, etc. All compounds were screened for their antimicrobial activity. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Computed Properties of C12H8N4O).
2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C12H8N4O