Late-stage synthesis and application of photoreactive probes derived from direct benzoylation of heteroaromatic C-H bonds was written by Hesp, Kevin D.;Xiao, Jun;West, Graham M.. And the article was included in Organic & Biomolecular Chemistry in 2020.SDS of cas: 59718-84-2 This article mentions the following:
A C-H functionalization strategy for the expedient access to photoreactive chem. probes of commonly found heterocyclic fragments RC6H4C(O)R1 [R = H, 4-(CHCCH2O), 4-N3, 3-(CHC), etc.; R1 = pyrazin-2-yl, isoquinolin-1-yl, pyridazin-4-yl, etc.] or drug mols. of pharmaceutical relevance is described. A series of aryl glyoxylic acid reagents featuring pendant alkyne or azide clickable handles RC6H4C(O)C(O)OH have been developed for application in the radical-mediated appendage of benzoyl fragments onto simple heteroaromatic fragments RC6H4C(O)R1, as well as more complex drug-like compounds This unprecedented strategy of chem. probe synthesis allows for direct access to photoreactive chem. probes without any requirement of fragment pre-functionalization or significant synthetic re-evaluation. In the experiment, the researchers used many compounds, for example, Methyl 3-methylpicolinate (cas: 59718-84-2SDS of cas: 59718-84-2).
Methyl 3-methylpicolinate (cas: 59718-84-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 59718-84-2