Rhodium(III)-Catalyzed Activation of Csp3-H Bonds and Subsequent Intermolecular Amidation at Room Temperature was written by Huang, Xiaolei;Wang, Yan;Lan, Jingbo;You, Jingsong. And the article was included in Angewandte Chemie, International Edition in 2015.Category: pyridine-derivatives This article mentions the following:
Disclosed herein is a RhIII-catalyzed chelation-assisted activation of unreactive Csp3-H bonds, thus enabling an intermol. amidation of 2-alkylpyridines I (R1 = H, 4-Me, 5-F, 5-Me, 5-MeO; R2 = R3 = Me, Ph; R2 = n-Bu, MeO2C, EtOCH2, etc., R3 = Me) with amides and sulfonamides R3NH2 (R3 = F3CCO, MeSO2, 4-O2NC6H4SO2, etc.) to provide a practical and step-economic route to 2-(pyridin-2-yl)ethanamine derivatives II. Substrates with other N-donor groups (3-isoquinolinyl, cyclohexylideneaminooxy, 5,6-dihydro-1,4,2-dioxazin-3-yl, etc.) are also compatible with the amidation. This protocol proceeds at room temperature, has a relatively broad functional group tolerance and high selectivity, and demonstrates the potential of rhodium(III) in the promotive functionalization of unreactive Csp3-H bonds. A rhodacycle having a SbF6– counterion was identified as a plausible intermediate. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Category: pyridine-derivatives).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives