Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 6602-54-6, Name is 2-Chloronicotinonitrile, molecular formula is C6H3ClN2. In an article, author is Vetel, Steven,once mentioned of 6602-54-6, Recommanded Product: 2-Chloronicotinonitrile.
Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic alpha 7 and sigma 1 receptors in a rat model of Parkinson’s disease
To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease. It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the alpha 7 subtype of nicotinic acetylcholine receptor (alpha 7-nAChR) and sigma-1 receptor (sigma 1-R) could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s disease. In this context, the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide (PHA) 543613 as an alpha 7-nAChR agonist and 2-(4-morpholinethyl) 1-phenylcyclohexanecarboxylate (PRE)-084 as a sigma 1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s disease. The animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 postlesion. Although no effect was noticed in the amphetamine-induced rotation test, our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons (15-20%), assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra. Furthermore, this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion, i.e, the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum, and the CD11b and glial fibrillary acidic protein staining in the substantia nigra. Hence, this study reports for the first time that concomitant activation of alpha 7-nAChR and sigma 1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial activation.
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