Electric Literature of 1159820-58-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1159820-58-2, name is 5-Bromo-2-isopropylpyridine, molecular formula is C8H10BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation of 2-isopropyl-5-vmyl-py?dme[0369] The title compound was prepared by following general procedure 2 5-Bromo-2- lsopropyl-py?dme (0 75 g, 3 7 mmol) was dissolved in DMF THF (3 1, 6 mL) T?butylvmyltm (1 2 mL, 4 12 mmol) and Pd(PPh3)4 (0 070 g, 0 06 mmol) was added to this solution at RT under nitrogen and was heated at 1000C for 30 mm The reaction mixture was cooled to RT and diluted with water (60 mL) and extracted with DCM (3 x 100 mL) The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure below 400C The crude was purified through column chromatography (90% DCM-Hexane in silica 100-200 mesh, Diameter of column – 5 0 cm, Height of silica – approx 5 inch) to provide 2-isopropyl-5- vmylpy?dme as a light yellow liquid (0 5 g, 90% yield)
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Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; HUNG, David, T.; PROTTER, Andrew, Asher; JAIN, Rajendra, Parasmal; CHAKRAVARTY, Sarvajit; GIORGETTI, Marco; WO2010/51503; (2010); A1;,
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