Experimental and theoretical studies on rhodium-catalyzed direct C-H benzoxylation reaction was written by Jin, Chen;Wang, Guimin;Yang, Xueyan;Zhu, Weiliang;Yang, Yaxi. And the article was included in Tetrahedron Letters in 2018.Related Products of 4373-61-9 This article mentions the following:
The green and efficient rhodium-catalyzed, chelation assisted C-H benzoxylation reaction of electron donating group containing benzenes with hydroxy-benziodoxolone was developed to yield mono-oxidation i.e. I [R = H, 3-Me, 4-OMe, etc.; R1 = 2-pyridyl, 2-pyrimidinyl, 1-pyrazolyl; R2 = OC(O)-2-I-C6H4] and di-oxidation i.e. II products which released water as the single byproduct. The reaction proceeded under mild conditions with controllable mono- and dioxygenation selectivity. DFT calculations supported the nucleophilic addition pathway was most likely involved in the current reaction system. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Related Products of 4373-61-9).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Related Products of 4373-61-9