Synthesis, molecular modeling and evaluation of α-glucosidase inhibition activity of 3,4-dihydroxy piperidines was written by Kasturi, Siva Prasad;Surarapu, Sujatha;Uppalanchi, Srinivas;Dwivedi, Shubham;Yogeeswari, Perumal;Sigalapalli, Dilep Kumar;Bathini, Nagendra Babu;Ethiraj, Krishna S.;Anireddy, Jaya Shree. And the article was included in European Journal of Medicinal Chemistry in 2018.Formula: C10H17NO2 This article mentions the following:
Biol. evaluation of 3,4-dihydroxy piperidines I and II [R = 4-fluorophenyl, styryl, 2-(4-hydroxyphenyl)ethyl, 3-thienylsulfonyl, etc.] as α-glucosidase inhibitors was reported for the first time. Forty-five compounds I and II (amides, di-amides and sulfonamides) were made using cis- and trans-3,4-dihydroxy piperidines to evaluate their α-glucosidase inhibition activity. Polar groups (-OH, -NH2) on Ph ring having compounds I and II [R = 2-(4-hydroxyphenyl)ethyl, 2-(4-aminophenyl)ethyl] showed excellent activity compared to standard references Acarbose, Voglibose and Miglitol were used as standard references Mol. docking simulations were done for compounds I and II to identify important binding modes responsible for inhibition activity of α-glucosidase. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Formula: C10H17NO2).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C10H17NO2