Khvostov, Mikhail Vladimirovich published the artcileStudy of supramolecular complex of nifedipine with arabinogalactan on Wistar and ISIAH rats, Formula: C17H18N2O6, the main research area is nifedipine arabinogalactan hypotensive action pharmacokinetics; arabinogalactan; bioavailability; complexes; drug delivery; mechanochemistry; nifedipine.
Aim: Physicochem. and pharmacol. study of the supramol. inclusion complexes of the hypotensive drug nifedipine (NF) with the larch polysaccharide arabinogalactan (AG). Materials & methods: The NF:AG complexes were obtained and their physicochem. properties were studied. Their hypotensive action and pharmacokinetic profiles were evaluated in rats with normal and elevated arterial blood pressure. Results: In both rat lines the NF:AG complex decreased the arterial blood pressure at a lower dose than free NF (1.75 mg/kg of NF in complex compared with 3.5 mg/kg of free NF) and has a better pharmacokinetic profile than free NF. Conclusion: The use of the NF:AG complex is an effective way to sufficiently enhance and hasten NF’s hypotensive action.
Therapeutic Delivery published new progress about Blood pressure. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Formula: C17H18N2O6.