Water as a Hydroxy Source in a RhIII-Catalyzed Directed C-H Hydroxylation of 2-Arylpyridines was written by Kim, Kiseong;Hyun, Jaeyong;Kim, Jin;Kim, Hyunwoo. And the article was included in Asian Journal of Organic Chemistry in 2017.COA of Formula: C12H11N This article mentions the following:
A [RhIIICp*]-catalyzed directed C-H hydroxylation of 2-arylpyridines was described (Cp*=1,2,3,4,5-pentamethylcyclopenta-2,4-dienyl), in which the combination of [(RhCp*Cl2)2]/AgF, PhI(OPiv)2 and water was used as an effective catalytic system. According to mechanistic studies, including 18O-labeling experiments and X-ray crystallog. anal. of an intermediate Rh complex, it was demonstrated that water and PhI(OPiv)2 were required for Rh catalysis as the hydroxy source and the oxidant, resp. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9COA of Formula: C12H11N).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C12H11N