Thermodynamics of protonation of pyridine N-oxide and its methyl-substituted derivatives in aqueous media was written by Klofutar, C.;Paljk, S.;Kremser, D.. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 1973.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:
Thermodn. protonation constants of pyridine N-oxide and its Me derivatives are measured spectrophotometrically from 20-60°. The substituent effect on the free energy of proton ionization is additive, and an approx. linear relation exists between the pKa values of pyridine N-oxides and those of the pyridines. The changes of reaction enthalpy and entropy are discussed in terms of internal and external contributions of thermodn. functions. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 3,5-Dimethylpyridine 1-oxide