Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant was written by Kuduk, Scott D.;Skudlarek, Jason W.;Di Marco, Christina N.;Bruno, Joseph G.;Pausch, Mark A.;O’Brien, Julie A.;Cabalu, Tamara D.;Stevens, Joanne;Brunner, Joseph;Tannenbaum, Pamela L.;Gotter, Anthony L.;Winrow, Christopher J.;Renger, John J.;Coleman, Paul J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Formula: C6H6BrNO This article mentions the following:
Analogs of the dual orexin receptor antagonist filorexant were prepared Replacement of the ether linkage proved highly sensitive toward modification with an acetylene linkage providing compounds with the best in vitro and in vivo potency profiles. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Formula: C6H6BrNO).
(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C6H6BrNO