Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organo-phosphate scavengers was written by Le Provost, Romain;Wille, Timo;Louise, Ludivine;Masurier, Nicolas;Mueller, Susanne;Reiter, Georg;Renard, Pierre-Yves;Lafont, Olivier;Worek, Franz;Estour, Francois. And the article was included in Organic & Biomolecular Chemistry in 2011.Related Products of 1620-76-4 This article mentions the following:
A new generation of organo-phosphate (OP) scavengers was obtained by synthesis of β-cyclodextrin-oxime derivatives Selective mono-substitution of β-cyclodextrin was the main difficulty in order to access these compounds, because reaction onto the oligosaccharide was closely related to the nature of the incoming group. For this purpose, non-conventional activation conditions were also evaluated. OP hydrolytic activity of compounds was evaluated against cyclosarin (GF) and VX. None of the tested compounds was active against VX, but these five cyclodextrin derivatives detoxified GF, and the most active scavengers allowed an almost complete hydrolysis of GF within 10 min. Even more fascinating is the fact that title compounds were able to hydrolyze enantioselectively GF. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Related Products of 1620-76-4).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 1620-76-4