Levin, Gabriel published the artcileNifedipine versus ritodrine during external cephalic version procedure: a case control study, Product Details of C17H18N2O6, the main research area is nifedipine ritodrine external cephalic version procedure; Amniotic fluid index; breech; external cephalic version; nifedipine; ritodrine.
Published series regarding interventions for facilitating external cephalic version (ECV) have concluded that parenterally administered beta-stimulant tocolytics, increased ECV success rate and reduced the number of cesarean sections. However, there were insufficient data regarding calcium channel blockers to provide good evidence regarding its efficacy. Given the paucity of literature, we aimed to compare the efficacy of nifedipine to that of ritodrine on ECV success rates. This is a retrospective case control study of prospectively collected data of patients who underwent ECV between Jan. 2012 and Dec. 2013 at Bikur Cholim Medical Center and Hadassah-Hebrew University Medical Center in Jerusalem, Israel. Patient undergoing ECV with tocolysis by ritodrine were compared with those using nifedipine as tocolysis. Patients were matched in a one-to-one ration by parity and placental location. Overall, 148 women received ritodrine and 148 women received nifedipine before ECV procedure. Overall success rate was higher among the ritodrine group (82.4 vs. 63.5%, p> .001). Among nulliparous and among parous, success rate was higher in the ritodrine group (78.9 vs. 57.9 and 88.6 vs. 73.5%, p = .001, p = .04, resp.). Vaginal delivery rate was higher among the ritodrine group (86.5 vs 68.9%, p >.001). Cesarean delivery rate was 31.1% for the nifedipine group vs. 13.5% in the ritodrine group (p > .001). Number needed to treat to benefit (NNTb) 5.7 (95% confidence interval 3.7-12.1). Overall, 216 of 296 (72.9%) of ECV were successful. Ritodrine was associated with higher success rates as compared with nifedipine (56.5 vs. 32.5%, p > .001). In a multivariate anal., ritodrine tocolytic therapy was independently associated higher ECV success rates as compared to nifedipine (OR 4.54, 95% CI 2.38-9.09). Higher amniotic fluid index (OR 1.16, 95% CI 1.05-1.28) and nulliparity (OR 0.16, 95% CI 0.08-0.30) were addnl. independent predictors of ECV outcome. Ritodrine significantly improve the success of ECV compared with nifedipine. Both drugs are shown to be safe.
Journal of Maternal-Fetal & Neonatal Medicine published new progress about Amniotic fluid. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Product Details of C17H18N2O6.