Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions was written by Liu, Jianzhong;Wu, Kai;Shen, Tao;Liang, Yujie;Zou, Miancheng;Zhu, Yuchao;Li, Xinwei;Li, Xinyao;Jiao, Ning. And the article was included in Chemistry – A European Journal in 2017.Quality Control of 3-Amino-2,6-dimethoxypyridine This article mentions the following:
A novel and efficient Fe-catalyzed direct C-H amination (NH2) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds Mechanistic studies demonstrate that a radical pathway could be involved in this transformation. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Quality Control of 3-Amino-2,6-dimethoxypyridine).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 3-Amino-2,6-dimethoxypyridine