Rhodium(II)-Catalyzed Formal [4+1]-Cycloaddition of Pyridotriazoles and Propargyl Alcohols: Synthesis of 2,5-Dihydrofurans was written by Lv, Xinxin;Yang, Haijian;Shi, Taoda;Xing, Dong;Xu, Xinfang;Hu, Wenhao. And the article was included in Advanced Synthesis & Catalysis in 2019.Quality Control of Methyl 2-(5-bromopyridin-2-yl)acetate This article mentions the following:
A rhodium-catalyzed formal [4+1]-cycloaddition of pyridotriazoles, e.g., I and aryl propargyl alcs. ArCCCH2OH (Ar = 4-methylphenyl, naphth-1-yl, 2-bromophenyl, etc.) is reported, providing an effective access to 2-pyridyl-substituted 2,5-dihydrofuran derivatives II (R = Me, Et, t-Bu; Ar1 = 6-chloropyridin-2-yl, 4,5-diphenyloxazol-2-yl, 3-bromopyridin-2-yl, etc.) in moderate to high yields. Mechanistically, the proposed oxonium ylide intermediate in this catalytic alkyne carbocyclization transformation is verified by an interception experiment for the first time. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Quality Control of Methyl 2-(5-bromopyridin-2-yl)acetate).
Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of Methyl 2-(5-bromopyridin-2-yl)acetate